Treatment of Perianal Condyloma Acuminate with Topical ALA-PDT Combined with Curettage: Outcome and Safety

Lu, Yuangang; Yang, Yadong; Wu, Jinjin; Xia, Lei; Cheng, Qi; He, Yonghong; Yang, Wen

doi:10.1089/pho.2011.3040

Cited by 22 publications

(12 citation statements)

References 15 publications

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“…Lu et al. performed a total of 3 PDT sessions at two‐week intervals; all 40 patients exhibited complete resolution, with a recurrence rate of only 15 % after three months . Although none of these studies was placebo‐controlled, but merely prospective, they do suggest interesting approaches that have encouraged us to employ photodynamic therapy, especially in case of recurrent condylomata acuminata in the anal region.…”

Section: Genital Wartsmentioning

confidence: 99%

Therapeutic management of cutaneous and genital warts

Ockenfels

2016

J Deutsche Derma Gesell

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SummaryDuring their lifetime, at least 10 % of the population will be infected by human papillomaviruses (HPV), clinically characterized by the formation of cutaneous or genital warts. Although warts are ubiquitous, there are no defined treatments. Especially in the first six months, warts frequently resolve without therapeutic intervention. This complicates the interpretation of study data, given that many studies do not differentiate between newly infected patients and those with infections that have persisted for a long time. Similarly, most studies do not take location, size, and thickness of lesions into account, either. The objective of the present review article is to analyze the study data currently available, taking into consideration both subtypes and locations -factors exceedingly crucial in clinical practice. In particular, the distinction between new-onset and chronic recalcitrant warts is reflected in a therapeutic algorithm. In the case of genital warts, the algorithm is more clearly determined by the extent of the area affected rather than the longevity of lesions. In immunocompetent individuals, any therapeutic intervention must be aimed at achieving complete resolution.

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Section: Genital Wartsmentioning

confidence: 99%

Therapeutic management of cutaneous and genital warts

Ockenfels

2016

J Deutsche Derma Gesell

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“…Due to subclinical and latent HPV infection, CA has a high recurrence rate and is difficult to cure completely [17,18,19]. Conventional treatments are sufficient to remove visible warts, but HPV infection may continue to exist around the skin lesions and contribute to recurrence and potentially even genital tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinical Analysis of Five Methods Used to Treat Condylomata Acuminata

Shi

Zhang²,

Ma³

et al. 2013

Dermatology

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Objective: Treatments for condylomata acuminata (CA) include pharmacotherapy and surgical therapies, but each treatment has its limitations. The aim of this study was to investigate the virus clearance rate, wart cure rate and safety of 5 methods on CA. Methods: 361 patients diagnosed with CA were divided into groups A (<0.5 cm), B (0.5-2.0 cm) and C (>2.0-4.0 cm) according to the maximum diameter of their lesion. Five treatments were compared in each group, and the clinical outcomes were evaluated during follow-ups. Results: A 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is preferred if the maximum lesion diameter is <0.5 cm and an ALA-PDT plus cryotherapy treatment is preferred for lesions 0.5-2.0 cm. For lesions >2.0- 4.0 cm, an ALA-PDT retreatment (after cryotherapy or CO₂ laser treatment) should be the first choice. Conclusions: The treatments for CA should be chosen according to the maximum diameter of each patient's lesion.

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“…Lu et al. führte bei 40 Patienten insgesamt drei PDT‐Sitzungen im Abstand von je zwei Wochen durch, wobei alle 40 Patienten eine vollständige Abheilung und nach drei Monaten eine Rezidivrate von nur 15 % aufwiesen . Obwohl es sich bei allen diesen Arbeiten um nicht placebokontrollierte, sondern nur um prospektive Studien handelt, sind es interessante Ansätze, die uns ermutigen, insbesondere bei wiederkehrenden Condylomata acuminata im Analbereich, eine photodynamischer Therapie durchzuführen.…”

Section: Genitale Verrucaeunclassified

Therapeutisches Management kutaner und genitaler Warzen

Ockenfels

2016

J Deutsche Derma Gesell

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Mindestens 10 % der Bevölkerung erkranken während ihres Lebens an einer Infektion mit humanen Papillomaviren (HPV), welche sich klinisch anhand der Ausbildung kutaner oder genitaler Warzen manifestiert. Obwohl Warzen ubiquitär sind, existieren keine definierten Behandlungen. Warzen zeigen, insbesondere in den ersten sechs Monaten, eine erhöhte Selbstheilungsrate. Dieser Umstand erschwert die Interpretation von Studien, da häufig Patienten mit Neuinfektionen zusammen mit Patienten mit Altinfektionen behandelt werden. Lokalisationen, Größe und Dicke der Warzen sind ebenfalls in den meisten Fällen nicht berücksichtigt. Ziel dieses Übersichtsartikels ist eine Analyse des vorliegenden Studienmaterials, unter der für den klinischen Alltag so wichtigen Berücksichtigung von Subtypen und Lokalisationen. Insbesondere die Abgrenzung zwischen frischen und chronisch-therapieresistenten Verrucae vulgares spiegelt sich in einem Therapiealgorithmus wider. Bei genitalen Warzen wird der Therapiealgorithmus deutlicher durch das Ausmaß der infizierten Fläche als durch das Alter der Warzen bestimmt. Bei immunkompetenten Personen muss es mit den hier aufgezeigten therapeutischen Methoden immer das Ziel sein, eine komplette Abheilung zu erzielen.

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Treatment of Perianal Condyloma Acuminate with Topical ALA-PDT Combined with Curettage: Outcome and Safety

Abstract: Combination of surgical curettage and topical PDT has been proven to be a safe and effective procedure, and may offer a wide clinical application for the treatment of perianal condyloma acuminata.

Cited by 22 publications

References 15 publications

Therapeutic management of cutaneous and genital warts

Therapeutic management of cutaneous and genital warts

Clinical Analysis of Five Methods Used to Treat Condylomata Acuminata

Therapeutisches Management kutaner und genitaler Warzen

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