Treatment of penile carcinoma: To cut or not to cut?

Ozşahin, Mahmut; Jichlinski, Patrice; Weber, Damien Charles; Azria, D.; Zimmermann, Michel; Guillou, Louis; Bulling, S.; Moeckli, Raphaël; Mirimanoff, R.O.; Zouhair, Abderrahim

doi:10.1016/j.ijrobp.2006.05.053

Cited by 59 publications

(28 citation statements)

References 39 publications

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“…All our patients received EBRT and 1 received combined EBRT and bra-chytherapy. Reported SS in PC patients treated by EBRT ranges 29-61% [7,11,24]. In Azrif et al [7] study, 12/41 (29.26%) patients who received RT developed a biopsy confirmed local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrences were salvaged by partial/total penectomy according to the urologist preference. In Ozsahin et al [11] study, 19/33 (57.5%) patients developed local failure after pri-mary RT. SS varied between total, partial penectomy and local excision.…”

Section: Discussionmentioning

confidence: 99%

“…The reported rate of SS following RT is 12-61% [6,7,8,9]. Reports describing the survival outcome of those patients are rare, usually institutional experiences and are usually reported with the overall survival (OS) outcome of RT [10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

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Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study

et al. 2019

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Objective: Salvage surgery (SS) for penile cancer (PC) is indicated in the management of local failure following radiation therapy (RT). Reports describing survival outcome are rare. This study aims to assess survival outcome of SS following RT failure in PC. Materials and Methods: We used The Surveillance, Epidemiology, and End Results database to identify patients received SS on the penis following RT. Social, demographic and pathological criteria of the patients were gathered. The 1-, 3-, 5-, 10-year survival rates were assessed. Results: Between 1976 and 2013, 17 patients received penile SS following RT. Median age was 65 years (range 47-91 years). The mean follow-up was 51 months (range 3-213 months). Sixteen (94.12%) patients received external beam radiation and 1 (5.88%) received combined external beam radiation with brachytherapy. Tumor histology was squamous cell carcinoma in 16 (94.12%) patients and mucinous adenocar-cinoma in 1 (5.88%). The 1-, 3-, 5- and 10-year overall survival rates were 68.8, 35.7, 35.7 and 10.7%, respectively. The 1-, 3-, 5- and 10-year cancer specific survival rate was 72.7, 48.4, 48.4, and 36.3% respectively. Conclusion: Our results demonstrate, the overall survival of PC patients underwent SS was poor with nearly one third of patients dying within the first year and only one third surviving up to 3 years from the SS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study

et al. 2019

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“…BT offers good success rates particularly for low-stage disease and in general is more successful than EBRT. The 5-year rate of penile preservation after BT ranges from 70 to 88%, which is higher than the corresponding 36-66% rates for EBRT [18][19][20]. The American Brachytherapy Society and the Groupe Européen de Curiethérapie-European Society of Therapeutic Radiation Oncology (ABS-GEC-ESTRO) consensus statement for penile brachytherapy reported good tumor control rates, acceptable morbidity, and functional organ preservation for penile brachytherapy for T1 and T2 penile cancers [21].…”

Section: Radiotherapymentioning

confidence: 99%

Organ Preservation Surgery for Carcinoma Penis

Yuvaraja

Waigankar

Dharmadhikari

et al. 2016

Indian J Surg Oncol

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Carcinoma of the penis is not uncommon in India. A sizeable number of patients do not report to the doctors in fear of mutilation to the organ and hence subsequently end up with advanced disease. Many patients with T1 or T2 disease when carefully selected are amenable to organ-preserving penile procedures including surgery, topical therapy, laser, and radiation therapy. Identification of appropriate patients and institution of these treatments has been noted to produce oncologically comparable results to extirpative surgeries. In this article, we review the criteria to identify patients qualifying for organ-preserving treatments and also review outcomes with a variety of penile-preserving procedures.

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“…Radiation, both by brachytherapy and external beam radiotherapy, preserves function and establishes cancer control in select patients (29)(30)(31). Phallic preservation is possible in over half to three-quarters of those treated in this manner.…”

Section: Surgery Of the Primary Tumormentioning

confidence: 99%

Update in the management of penile cancer

et al. 2009

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Purpose: The management of penile cancer has evolved as less invasive techniques are applied in the treatment of the primary tumor and inguinal lymph nodes. Materials and Methods: Herein we review the literature focusing on advances in the preservation of the phallus as well as less morbid procedures to evaluate and treat the groins. Results: Promising imaging modalities for staging are discussed. New techniques are described and tables provided for penile preservation. We also review the contemporary morbidity of modified surgical forms for evaluation of the inguinal nodes. Conclusions: Advances in surgical technique have made phallic preservation possible in a greater number of primary penile cancers. The groins can be evaluated for metastasis with greater accuracy through new radiologic means as well as with less morbid modified surgical techniques.

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Treatment of penile carcinoma: To cut or not to cut?

Cited by 59 publications

References 39 publications

Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study

Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study

Organ Preservation Surgery for Carcinoma Penis

Update in the management of penile cancer

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