Treatment of Pemphigus With Corticosteroids

Costello, Maurice J.

doi:10.1001/jama.1957.02980280023007

Cited by 44 publications

(8 citation statements)

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(1 reference statement)

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“…The patients in this series showed a formidable list of side-effects from corti- Osteoporosis (fractures included) 9 9 18 (Table 7). In the large doses employed, the various compounds showed similar untoward effects, except that weakness seemed to be more pronounced in the patients who received the newer corti¬ costeroid derivatives.…”

Section: Side-effects and Complications Of Corticosteroid Therapymentioning

confidence: 91%

Corticosteroid Treatment of Pemphigus

Sanders¹

1960

Arch Dermatol

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Section: Side-effects and Complications Of Corticosteroid Therapymentioning

confidence: 91%

Corticosteroid Treatment of Pemphigus

Sanders¹

1960

Arch Dermatol

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“…Bacterial Infections.-Bacterial infections occurred in 10 patients, with a fatal outcome in 2. One patient died of staphylococcal sep¬ ticemia (Case 5) and the other of chronic pyelonephritis with septicemia (Case 16) (see under Causes of Death); As reported in a previous paper,14 patients had staphylo¬ coccal abscesses at sites of intramuscular in¬…”

mentioning

confidence: 56%

Treatment of Pemphigus with Corticosteroids

Lever¹

1963

Arch Dermatol

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“…In approximately 50% of patients, all therapy can be discontinued, and patients will remain lesion free for months to years. 54 A recent study reported remission rates of 38%, 50% and 75% achieved 3, 5 and 10 years from diagnosis, respectively 55 Corticosteroids were first applied to patients with the disease by Thorn et al 56 and were later more widely used by Costello et al 57 and Lever and White. 58 Since then, various regimens regarding their administration have been introduced, dictated by the age of the patient, the degree of involvement, the rate of disease progression and the subtype of pemphigus.…”

Section: Treatmentmentioning

confidence: 99%

“…Corticosteroids were first applied to patients with the disease by Thorn et al 56 . and were later more widely used by Costello et al 57 . and Lever and White 58 .…”

Section: Treatmentmentioning

confidence: 99%

Pemphigus

Ioannides

Lazaridou

Rigopoulos³

2008

Acad Dermatol Venereol

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Pemphigus refers to a group of potentially life-threatening autoimmune diseases of the skin and mucous membranes, characterized by the formation of blisters and erosions of the skin. An autoimmune process, directed against keratinocyte desmosomal cadherins, interferes with the adhesive function of these molecules. This results in the separation of keratinocytes and clinical manifestation of blistering. Differences in the particular antigens targeted by the antibodies and in the distribution of these antigens in the different regions of the body and in the separate layers of the epidermis result in different clinical manifestations of the disease. Diagnosis of pemphigus is based on three independent groups of criteria: clinical features (flaccid blisters and erosions on skin and oral mucosa), histologic findings (epidermal acantholysis) and immunological tests (circulating and skin-fixed antibodies against keratinocyte surface antigens). The principle aim of treatment is to reduce inflammatory response and autoantibody production, thereby achieving disease remission.Systemic corticosteroids are still the most useful drugs in the treatment of pemphigus and continue to be the mainstay of therapy for this disease.Adjuvant drugs, such as immunosuppressants, are commonly used in combination, in order to increase efficacy and have a steroid-sparing effect,thereby allowing reduced maintenance doses and less side effects of systemic corticosteroids. Other options include intravenous immunoglobulin and plasmapheresis. However, more research is needed to develop treatments with the least possible toxicity.

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Treatment of Pemphigus With Corticosteroids

Cited by 44 publications

References 1 publication

Corticosteroid Treatment of Pemphigus

Corticosteroid Treatment of Pemphigus

Treatment of Pemphigus with Corticosteroids

Pemphigus

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