“…biological, psychological, social, and environmental, of TMD-M, 12,13 one cannot rule out the possibility that TMD-M might just be a result of distinct receptor mechanisms, 14 since the majority of TMDs do not show signs of inflammatory changes. 15,16 Due to the variety of symptoms and complex aetiology in chronic pain patients, and especially TMD-M, a multimodal treatment approach is recommended. As implied, this includes a broad spectrum of different therapies, such as occlusal splints, pharmacological treatment, physiotherapy, behavioural therapy, and other therapies.…”