Treatment of Parthenium dermatitis with methotrexate

Abstract

Patients with parthenium dermatitis are often unresponsive to topical steroids, and immunosuppressive agents may be necessary to reduce their need for systemic corticosteroids. We evaluated the efficacy of methotrexate in parthenium dermatitis. Sixteen patients unresponsive to topical treatment were included after baseline investigations, and treated with oral methotrexate (15 mg/week). Clinical response was monitored using a dermatitis area and severity index (DASI). Seven patients completed >or=6 months' follow-up, and their mean DASI fell to 5, 2.7 and 2.1 at the end of 1, 3 and 6 months respectively, from a baseline score of 10. Only 3/7 patients required oral prednisolone in the initial 2-4 weeks. Side effects were minor, being mainly folliculitis and furuncles. Methotrexate may hence be a useful alternative for patients with severe parthenium dermatitis.

The comparative efficacy and safety of azathioprine vs methotrexate as steroid-sparing agent in the treatment of airborne-contact dermatitis due to Parthenium

“…The beneficial effect of methotrexate in parthenium dermatitis studied previously showed 50% improvement in dermatitis within 1 month of initiation of therapy with a sustained decrease in the dermatitis score with continuation of methotrexate for 6 months. [6] Our study, also shows >75% reduction in CSS within 5.6 weeks. In conclusion, though both azathioprine and methotrexate are effective and safe steroid-sparing agents in the treatment of parthenium-induced ABCD, methotrexate helps in achieving an earlier control of the dermatitis and is a cheaper alternative to azathioprine.…”

Contact dermatitis to parthenium weed treated with methotrexate and triamcinolone acetonide

“…A trial with dexamethasone-cyclophosphamide pulse therapy was unsuccessful 15. Methotrexate has also been reported to be effective at a dose of 15 mg/week along with topical corticosteroids and sunscreens 16. There are no reports on CDP treated with methotrexate and intralesional triamcinolone acetonide.…”

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

“…Bu ilk adımdan sonra topikal (steroidler, topikal kalsinörin inhibitörler, nemlendiriciler) ve sistemik (steroidler, metotreksat, azothioprin) gibi birçok ajan kullanılabilir (42)(43)(44)(45)(46). Ancak tedavinin kısa ve uzun dönemde başarısının esas anahtarı kontakt dermatit etkenini bulup ortadan kaldırmaktır, nitekim ajanla teması kesilemeyen olgularda şikayetler işe dönünce tekrarlamaktadır (42).…”