Treatment of Paragonimus Westermani Infections with Bithionol

Kim, Joung Soon

doi:10.4269/ajtmh.1970.19.940

Cited by 18 publications

(6 citation statements)

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“…Skin rashes frequently occurred in patients with Parugominus westermani infections treated with bithionol (27). The cause was not clear, and they seemed to be related rather to the destruction of the worms in heavily infected patients than bithionol itself (27). In our study no patients had a skin rash.…”

Section: Discussioncontrasting

confidence: 67%

Successful treatment of acute fascioliasis with bithionol

Bacq

Besnier²,

Duong

et al. 1991

Hepatology

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Fascioliasis is the parasitic infestation of the liver and biliary tract related to Fasciola hepatica. Bithionol is proposed as the treatment of choice for human fascioliasis without major side effects. However, the efficacy of bithionol has been evaluated in chronic but not in acute fascioliasis. In this study we report on the success of treatment with bithionol in 10 patients with fascioliasis, 8 having acute fascioliasis. The criteria for the diagnosis of fascioliasis were hypereosinophilia, positive immunoelectrophoresis and indirect hemagglutination. Bithionol was given orally to hospitalized patients at the daily dose of 25 mg/kg body wt for 10 days. Three patients with acute fascioliasis received a second course of bithionol 2 or 3 mo after the first because of the recurrence of diarrhea and fatigue in one patient and persistent hypereosinophilia in two patients. All patients were cured. The follow-up period after the first course of treatment was between 16 and 47 mo. No major side effects were observed. We conclude that bithionol is the drug of choice for both acute and chronic fascioliasis. Moreover, its oral administration may allow treatment of fascioliasis in outpatients who do not have serious symptoms.

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Section: Discussioncontrasting

confidence: 67%

Successful treatment of acute fascioliasis with bithionol

Bacq

Besnier²,

Duong

et al. 1991

Hepatology

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“…In fact, both compounds were used as topical antiseptics before other alternatives became available. In addition, bithionol has successfully been used to treat outbreaks of the parasite Paragonimus westermani in humans, and can be taken orally at a concentration of 40 mg/kg every other day (Kim, 1970). To our knowledge, neither compound has been examined for its ability to treat a viral infection.…”

Section: Resultsmentioning

confidence: 99%

“…In fact, these compounds may be of use for the veterinary treatment of Avian Polyomavirus, which can cause acute death in a wide range of psittacine birds (Katoh et al, 2010). Further, in geographical regions where fluke outbreaks in humans are more problematic, bithionol has been used to successfully clear infections in humans after oral administration (Bacq et al, 1991; Kim, 1970; Lee and Kim, 2006; Price et al, 1993; Seo et al, 1982). …”

Section: Discussionmentioning

confidence: 99%

A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication

et al. 2012

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New polyomaviruses are continually being identified, and it is likely that links between this virus family and disease will continue to emerge. Unfortunately, a specific treatment for polyomavirus-associated disease is lacking. Because polyomaviruses express large Tumor Antigen, TAg, we hypothesized that small molecule inhibitors of the essential ATPase activity of TAg would inhibit viral replication. Using a new screening platform, we identified inhibitors of TAg's ATPase activity. Lead compounds were moved into a secondary assay, and ultimately two FDA approved compounds, bithionol and hexachlorophene, were identified as the most potent TAg inhibitors known to date. Both compounds inhibited Simian Virus 40 replication as assessed by plaque assay and quantitative PCR. Moreover, these compounds inhibited BK virus, which causes BKV Associated Nephropathy. In neither case was host cell viability compromised at these concentrations. Our data indicate that directed screening for TAg inhibitors is a viable method to identify polyomavirus inhibitors, and that bithionol and hexachlorophene represent lead compounds that may be further modified and/or ultimately used to combat diseases associated with polyomavirus infection.

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“…The side-effects of bithionol therapy were dose-dependent and transient and rarely so severe that the therapy had to be discontinued. Side-effects were seen less frequently in children than in adults (Yokogawa et al 1961(Yokogawa et al , 1963 and disappeared when medication was stopped (Bassiouny et al 1991, Chung et al 1981, Farag et al 1988, Gutman et al 1969, Kang et al 1963, Kim 1970, Oh 1967, Singh et al 1986, Wang et al 1964, Yokogawa et al 1961, 1962. One patient developed severe urticaria with respiratory distress after only three bithionol doses of 20 mg/kg body weight (2 x 20 mg/day on alternate days).…”

Section: Subchronic and Chronic Toxicitymentioning

confidence: 99%

“…The suggested causes of the skin reaction include allergic reactions to bithionol itself, effects of breakdown products or metabolites of bithionol (Yokogawa et al 1961), reaction to the increased antigen titre released from dead parasites (Kim 1970) or a Herxheimer-Jarisch reaction to the parasite toxins (Chung et al 1981).…”

Section: Volumementioning

confidence: 99%

Bithionol [MAK Value Documentation, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 9 (1998) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Acute toxicity Subchronic and chronic toxicity Local effects on skin and mucous membranes Effects on Animals Acute toxicity Subchronic and chronic toxicity Allergenic effects Contact sensitization in man Contact sensitization in animals Contact photosensitization in man Contact photosensitization in animals Genotoxicity Manifesto (MAK value, classification)

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Treatment of Paragonimus Westermani Infections with Bithionol

Cited by 18 publications

References 0 publications

Successful treatment of acute fascioliasis with bithionol

Successful treatment of acute fascioliasis with bithionol

A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication

Bithionol [MAK Value Documentation, 1998]

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