“…The work of Greenwood and Blyth (108) witJi capons suggests that, apart from the general action, its effect is greatest at and around the site of application ; Kun (144) reached a similar conclusion with rats. Baer (10) has shown that ketohydroxyoestrin is absorbed through the skin of spayed albino rats, and Palmer and Zuckerman (203) obtained a similar result with Ktilboestrol on mice. According to Kosakai, Okamoto and Kosuge (142), oestrogen is not excreted in the sweat.…”