S uperior vena cava (SVC) syndrome is a well-known disease entity that carries substantial rates of morbidity and mortality. Although most cases of SVC syndrome are secondary to a malignant process, 1 benign causes, such as pacemaker lead implantation, have been reported. 2 We present a case of SVC syndrome in a young woman after pacemaker implantation, whom we treated with venoplasty and stenting, aided by a balloon-in-balloon (BIB) catheter system.
Case ReportA 30-year-old woman with a known history of SVC stenosis presented to us for further evaluation and management of positional syncope. The patient had a history of sick sinus syndrome and of multiple radiofrequency ablations of the sinus node-hence the eventual need for a dual-chamber permanent pacemaker. She eventually underwent multiple revisions for lead malfunction and generator-site infection. She was next diagnosed, by means of computed tomography (CT), with SVC obstruction, after which she had a 5-cm saphenous vein bypass graft implanted from the right brachiocephalic vein to the right atrial appendage, through which the pacemaker leads were rerouted.When the patient presented to us, she reported chronic fatigue, shortness of breath, and palpitations that had progressively worsened. She also reported facial and neck swelling that was worse in the morning, along with positional syncope that occurred whenever she bent forward. On physical examination, she had slightly distended jugular veins, with only minor bilateral arm swelling at rest-and positional syncope was reproduced. Results of repeat chest CT scanning with contrast medium were consistent with SVC obstruction, as was near-occlusion of her SVC bypass graft. Venography then confirmed that the pacemaker leads were in an occluded saphenous vein graft and that she had longstanding SVC stenosis, with a large azygos vein "pop-off" to the inferior vena cava. There was no gradient across the SVC stenosis, given that the azygos vein was offloading flow from the SVC into the inferior vena cava. Both brachiocephalic veins were patent (Fig. 1). The native SVC was estimated to be 18 mm in diameter.At a later date, we proceeded with angioplasty and stent implantation at the SVC stenosis. Access was attained through the right common femoral vein with use of an 8F sheath. Heparin was used as an anticoagulant to maintain an activated clotting time of >200 s. An intravascular ultrasound catheter (Volcano Corporation; San Diego, Calif ) was advanced through the right common femoral vein for imaging of