Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3

Al-Qadreh, A.; Voskaki, I; Kassiou, C.; Athanasopoulou, Helen; Sarafidou, E.; Bartsocas, C. S.

doi:10.1007/bf02309849

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Osteoporosis is a recognised comorbidity in adults with T1DM , although there is conflicting evidence in children. De Shepper et al found bone density within normal limits, whereas Al‐Quadreh and Hamed et al have found deficits in bone density in children with diabetes. In support of the hypothesis that low vitamin D is a consequence rather than a risk for T1DM, the DAISY cohort study has found that low vitamin D was not a risk factor for development of insulin dependence in ‘at risk’ children followed longitudinally for up to 18 yr .…”

Section: Discussionmentioning

confidence: 98%

Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

et al. 2012

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Vitamin D is synthesised in the skin through the action of UVB radiation (sunlight), and 25-hydroxy vitamin D (25OHD) measured in serum as a marker of vitamin D status. Several studies, mostly conducted in high latitudes, have shown an association between type 1 diabetes mellitus (T1DM) and low serum 25OHD. We conducted a case-control study to determine whether, in a sub-tropical environment with abundant sunlight (latitude 27.5°S), children with T1DM have lower serum vitamin D than children without diabetes. Fifty-six children with T1DM (14 newly diagnosed) and 46 unrelated control children participated in the study. Serum 25OHD, 1,25-dihydroxy vitamin D (1,25(OH)(2) D) and selected biochemical indices were measured. Vitamin D receptor (VDR) polymorphisms Taq1, Fok1, and Apa1 were genotyped. Fitzpatrick skin classification, self-reported daily hours of outdoor exposure, and mean UV index over the 35 d prior to blood collection were recorded. Serum 25OHD was lower in children with T1DM (n = 56) than in controls (n = 46) [mean (95%CI) = 78.7 (71.8-85.6) nmol/L vs. 91.4 (83.5-98.7) nmol/L, p = 0.02]. T1DM children had lower self-reported outdoor exposure and mean UV exposure, but no significant difference in distribution of VDR polymorphisms. 25OHD remained lower in children with T1DM after covariate adjustment. Children newly diagnosed with T1DM had lower 1,25(OH)(2) D [median (IQR) = 89 (68-122) pmol/L] than controls [121 (108-159) pmol/L, p = 0.03], or children with established diabetes [137 (113-153) pmol/L, p = 0.01]. Children with T1DM have lower 25OHD than controls, even in an environment of abundant sunlight. Whether low vitamin D is a risk factor or consequence of T1DM is unknown.

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Section: Discussionmentioning

confidence: 98%

Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

et al. 2012

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“…Furthermore, one alpha-hydroxyvitamin D 3 was applied for the treatment of osteopenia in children with IDDM [155]. When in¯ammation and diabetes coexist, the spongy bone concentration is decreased further.…”

Section: Bone Density Studies In Diabetes Mellitusmentioning

confidence: 99%

The Greek contribution to diabetes research

Bartsocas

1999

Diabetes Metab. Res. Rev.

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Interest in diabetes mellitus research has escalated in Greece during the last decade. This may be attributed to the realization that diabetes is becoming a major problem for the Greek population, the effect of the St Vincent Declaration in passing speci®c government legislation, and the founding of the National Hellenic Center for the Prevention and Treatment of Diabetes and its Complications. Research areas include epidemiology, etiopathogenesis, glucose metabolism, complications, prevention and treatment of the disease.

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Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

Cantorna

2000

Proc Soc Exp Biol Med

215

122

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The environment in which the encounter of antigen with the immune system occurs determines whether tolerance, infectious immunity, or autoimmunity results. Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes. The active form of vitamin D has been shown to suppress the development of autoimmunity in experimental animal models. Furthermore, vitamin D deficiency increases the severity of at least experimental autoimmune encephalomyelitis (mouse multiple sclerosis). Targets for vitamin D in the immune system have been identified, and the mechanisms of vitamin D-mediated immunoregulation are beginning to be understood. This review discusses the possibility that vitamin D status is an environmental factor, which by shaping the immune system affects the prevalence rate for autoimmune diseases such as multiple sclerosis, arthritis, and juvenile diabetes.

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Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3

Cited by 4 publications

References 14 publications

Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

The Greek contribution to diabetes research

Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

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