Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3

Al-Qadreh, A.; Voskaki, I; Kassiou, C.; Athanasopoulou, Helen; Sarafidou, E.; Bartsocas, C. S.

doi:10.1007/bf02115619

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…Vitamin D deficiency or insufficiency has been documented in MS, IDDM, and RA patients (6–9). Vitamin D status is most often assessed because of reduced bone mass or osteopenia in these patients.…”

Section: Vitamin D Status In Iddm Ms and Ramentioning

confidence: 99%

“…Vitamin D status is most often assessed because of reduced bone mass or osteopenia in these patients. It is unclear whether vitamin D insufficiency is a cause or a result of autoimmunity and/or corticosteroid therapies, which are commonly used to treat these patients (6–9). Vitamin D supplements have been used in MS, RA, and IDDM patients to improve bone mineral density, but the effects of these supplements on the underlying autoimmune diseases have not been explored.…”

Section: Vitamin D Status In Iddm Ms and Ramentioning

confidence: 99%

“…Similarly, in patients with osteopenia, there is a clear and rational reason to suggest vitamin D treatment. Bone loss and osteopenia are two of the most crippling side effects of standard corticosteroid therapy (6–9). The most serious side effect of vitamin D treatment is hypercalcemia, which itself can be lethal.…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

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Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

Cantorna

2000

Proc Soc Exp Biol Med

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Abstract. The environment in which the encounter of antigen with the immune system occurs determines whether tolerance, infectious immunity, or autoimmunity results. Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes. The active form of vitamin D has been shown to suppress the development of autoimmunity in experimental animal models. Furthermore, vitamin D deficiency increases the severity of at least experimental autoimmune encephalomyelitis (mouse multiple sclerosis). Targets for vitamin D in the immune system have been identified, and the mechanisms of vitamin D‐mediated immunoregulation are beginning to be understood. This review discusses the possibility that vitamin D status is an environmental factor, which by shaping the immune system affects the prevalence rate for autoimmune diseases such as multiple sclerosis, arthritis, and juvenile diabetes.

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Section: Vitamin D Status In Iddm Ms and Ramentioning

confidence: 99%

Section: Vitamin D Status In Iddm Ms and Ramentioning

confidence: 99%

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Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

Cantorna

2000

Proc Soc Exp Biol Med

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“…Nonetheless, individuals with Type 2 diabetes possess higher spongy bone concentrations149–154. Furthermore, one alpha‐hydroxyvitamin D 3 was applied for the treatment of osteopenia in children with IDDM155.…”

Section: Complications Of Diabetes Mellitusmentioning

confidence: 99%

The Greek contribution to diabetes research

Bartsocas

1999

Diabetes Metab. Res. Rev.

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Interest in diabetes mellitus research has escalated in Greece during the last decade. This may be attributed to the realization that diabetes is becoming a major problem for the Greek population, the effect of the St Vincent Declaration in passing specific government legislation, and the founding of the National Hellenic Center for the Prevention and Treatment of Diabetes and its Complications. Research areas include epidemiology, etiopathogenesis, glucose metabolism, complications, prevention and treatment of the disease. Copyright © 1999 John Wiley & Sons, Ltd.

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“…Osteopenia is not uncommon in children and adolescents with DM1 [1]. The mechanism by which the bone loss occurs in diabetic patients could be explained by a reduction of insulin\insulin like growth factor 1 action, sustained hyperglycemic state, generation of glycosylation end--products, and diabetic complications such as neuropathy, nephropathy, and retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Effect of Physical Exercise on Bone Density and Remodeling in Egyptian Type 1 Diabetic Osteopenic Adolescents

Elhabashy

Said

Agaiby

et al. 2011

Diabetol Metab Syndr

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BackgroundThe study was planned to assess effect of physical exercise on bone remodeling in type I diabetics with osteopenia.MethodsTwenty-four type I diabetes mellitus (DM1) with osteopenia (10 females and 14 males) were compared to thirty-eight age- and sex-matched healthy control individuals (20 females and 18 males) for biochemical and radiologic parameters of bone mass. Laboratory investigations included serum and urinary calcium, inorganic phosphorus, alkaline phosphatase, and serum "procollagen type 1 N-terminal propeptide (P1NP). Bone densitometry was assessed at neck femur using Dual Energy X-ray Absorptiometry (DEXA). Serum P1NP and DEXA were reevaluated after a planned exercise program.ResultsPatients and controls were comparable with respect to serum as well as urinary biochemical parameters of bone mass namely; calcium, phosphorus and total serum alkaline phosphatase. Osteopenic DM1 patients displayed lower mean serum P1NP than control group (20.11 ± 6.72 ug\dL versus 64.96 ± 34.89 ug\dL; p < 0.05). A significant correlation was observed between BMD and degree of glycemic control reflected by serum glycated hemoglobin (r = -0.44, p, 0.030). Bone densitometry correlated with serum P1NP (r = -0.508, p, 0.011). After a planned regular exercise for 3 months, serum P1NP and BMD levels increased with percentage change of 40.88 ± 31.73 and 3.36 ± 2.94, respectively. Five patients resumed normal densitometry and they were all males.ConclusionDiabetic osteopenic patients displayed lower serum levels of procollagen type 1 N-terminal propeptide which reflects poor bone formation. A 3-months planned exercise program was associated with improvement of bone densitometry and significant increment of serum P1NP.

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Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3

Abstract: Osteopenia is not uncommon in children and adolescents with IDDM. In 10 children with IDDM and osteopenia the administration of 1 alpha-OHD3 for 1 year corrected bone loss.

Cited by 8 publications

References 15 publications

Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

The Greek contribution to diabetes research

Effect of Physical Exercise on Bone Density and Remodeling in Egyptian Type 1 Diabetic Osteopenic Adolescents

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