Treatment of osseous cyst‐like lesions

Jenner, Florien

doi:10.1111/eve.13269

Cited by 1 publication

(1 citation statement)

References 45 publications

(69 reference statements)

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“…Furthermore, a biochemical etiological component of the disease has also been identified [2], and the osteolytic activity of inflammatory metabolites produced by cystic tissue has been demonstrated. Nevertheless, in horses, SBCs are most commonly found in the medial condyle (MFC) of the femur, followed by phalanges, carpal bones, metacarpal and metatarsal bones, tibia, radius, talus, sesamoid bones, humerus, patella, and tarsal bones [3]. In general, both intermittent lameness and acute lameness can be observed soon after the onset of physical activity [4].…”

Section: Introductionmentioning

confidence: 99%

Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes

Canonici,

Marcoccia,

Bonini

et al. 2023

Biomedicines

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Subchondral bone cysts in horses represent one of the main causes of lameness that can occur in different anatomical locations. The study describes the treatment in regenerative therapy of the intracystic implantation of adipose tissue mesenchymal stromal cells (AMSCs) included in platelet-rich plasma (PRP). The ability of AMSCs to differentiate in osteogenic cells was tested in vitro and in vivo. Given the aim to investigate the application of AMSCs in bone defects and orthopedic pathologies in horses, a four-year-old male thoroughbred racing horse that had never raced before was treated for lameness of the left hind leg caused by a cyst of the medial femoral condyle. The horse underwent a new surgery performed with an arthroscopic approach in which the cystic cavity was filled with AMSCs contained in the PRP. Radiographs were taken 3, 5, and 10 months after the surgery to assess the development of newly regenerated bone tissue in the gap left by the cyst. Twelve months after the operation and after six months of regular daily training, the horse did not show any symptoms of lameness and started a racing career. According to the study, the use of AMSCs and PRP suggests promising benefits for treating subchondral bone cysts.

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Section: Introductionmentioning

confidence: 99%