Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

Köllner, Katja; Wimmershoff, M. B.; Landthaler, Míchael; Hohenleutner, Ulrích

doi:10.1002/lsm.10202

Cited by 62 publications

(40 citation statements)

References 13 publications

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“…Soliman et al 15 observed recurrence of OLP in only 3 patients out of 25 over period of 6-month follow up following the use of diode laser. The results in our study were contrast with studies conducted by Passeron et al, 18 Trehan and Taylor, 19 Kollner et al 20 Passeron et al 18 conducted a study using 308 nm-excimer lasers to treat erosive OLP in four patients with previous treatment failures, where 12 sessions were attended during 6 weeks, one patient showed partial remission, 2 were resistant to treatment and the other patient showed exacerbation of the lesion. The present study was conducted on patients, without any previous treatment of the lesion, while in the abovementioned studies, refractory cases were considered with different wavelengths (308 nm) compared to the present study (980 nm).…”

Section: Discussioncontrasting

confidence: 99%

Efficacy of Diode Laser for the Management of Potentially Malignant Disorders

et al. 2015

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Section: Discussioncontrasting

confidence: 99%

Efficacy of Diode Laser for the Management of Potentially Malignant Disorders

et al. 2015

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“…Topical application of psoralen is promising, but still experimental [17]. There was several case series which showed that treatment with the 308-nm excimer laser might be an additional treatment option for OLP [18][19][20]. However the results are still disappointing, so searching for new treatment modalities seems quite rational.…”

Section: Discussionmentioning

confidence: 99%

Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus

et al. 2006

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Background and Objectives: In this study, methylene blue-mediated photodynamic therapy (MB-PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP). Study Design/Materials and Methods: Thirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (l ¼ 632 nm, light exposure dose ¼ 120 J/cm 2 ). Lesions were evaluated pre and post-operatively and at follow-up sessions by changes in sign and symptom (pain) scores, and size of lesions. Results: Improvement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow-up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%. Conclusion: MB-PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.

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“…Aghahosseini et al [103] experienced the treatment of 26 lesions in 13 patients, evaluating the signs, symptoms and size of the lesions. A diode laser (632 nm, 120 J/cm 2 ) for 2 minutes was used.…”

Section: Laser Therapymentioning

confidence: 99%

Topical Therapies for Oral Lichen Planus Management and their Efficacy: A Narrative Review

Bagán

Compilato²,

Paderni³

et al. 2012

CPD

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Oral Lichen Planus (OLP) is a chronic inflammatory condition implicating T cell-mediated cytotoxicity, and involving oral mucosal surfaces. Several therapeutic regimens have been evaluated to treat OLP and pain related, but often without high level of evidence. Topical formulations are the favourite for the majority of cases; bioadhesive formulations have been considered very useful and practical for local drug delivery in oral mucosa, due to the increased residence time on the oral mucosa of the dosage forms and better therapeutic efficacy.In this narrative review, authors try to illustrate the current topical managements for OLP from the accessible literature on this topic. Steroids are very helpful in discomfort and making better quality of life: they are considered the first-line treatment even if they could cause secondary candidosis, and sometimes bad taste, nausea, dry mouth, sore throat or swollen mouth.Other substances or devices by topical administration are adopted especially when the first line approach is refractory. This is the case when retinol with its synthetic and natural analogues (retinoids), hyaluronic acid, or Aloe Vera are chosen.Recent topical applications for OLP therapy include phototherapy and low/high energy pulsing light; the treatment with extracorporeal photochemotherapy is also reasonable and promising.Finally, calcineurin inhibitors (i.e. cyclosporine, tacrolimus and pimecrolimus), antioxidant and biologics (i.e alefacept, efalizumab, basiliximab, TNF-inhibitors -infliximab, rituximab) may be alternative approaches when OLP does not respond to the standard protocols.In this scenario, there are several studies on molecules different from glucocorticosteroids, but not sufficient or statistically adequate to justify their evidence-based use in OLP; large randomized placebo controlled trials are required to evaluate the safety and effectiveness of these non conventional therapies.In conclusion, since OLP is a chronic disease and requires long-term management, the dental/medical practitioner, who treats OLP patients, needs to know the natural history of OLP, how to monitor, and how to treat, taking in account all of the available modalities conventional and not, with pros and cons.

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Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

Abstract: The preliminary results in our opinion warrant further studies of this treatment.

Cited by 62 publications

References 13 publications

Efficacy of Diode Laser for the Management of Potentially Malignant Disorders

Efficacy of Diode Laser for the Management of Potentially Malignant Disorders

Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus

Topical Therapies for Oral Lichen Planus Management and their Efficacy: A Narrative Review

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