Treatment of ocular metastasis with anti-VEGF: A literature review and case report

Augustine, Haley; Munro, Monique; Adatia, Feisal A.; Webster, Marc; Fielden, Michael

doi:10.1016/j.jcjo.2014.06.008

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…Although much of the literature reports satisfying local remission, there are many cases of failure. [ 16 , 17 ] In general, CM arising from BC often indicates a poor prognosis with an average survival time of 7 to 32 months. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

et al. 2018

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Rationale:Metastases of breast carcinoma to the main bronchus and choroid are rare, but have been reported in relevant literature. Late distant recurrence of breast carcinoma after more than 20 years is extremely rare. Herein, we report a 57-year-old woman with late distant recurrence and metastasis to the main bronchus and choroid almost 28 years after surgery.Patient concerns:At the age of 29, the patient underwent chemotherapy and endocrine treatment after a right side mastectomy to remove breast carcinoma. The patient was hospitalized for a cough with blood-tinged sputum, dysphagia, and blurred vision in the left eye at the age of 57.Diagnoses:On evaluation, laboratory findings detected the elevated serum tumor markers of CA12-5, CA15-3, NSE, and Cyfra21-1. The imaging showed left lung metastase, multiple lymph node metastases, and small suspected metastases in the both sides of parietal lobes. Fundus fluorescein angiography showed choroidal occupying lesion of the left side which indicates secondary metastasis and retinal detachment. Combined with the pathological finding via fiberoptic bronchoscopic biopsy, the patient was clinically diagnosed with a late distant recurrence of breast carcinoma.Interventions:The patient received oral endocrine therapy of letrozole, but she refused chemotherapy, radiotherapy and other topical treatments.Outcomes:At the 3-month follow-up visit, the multiple lesions of the left lung and lymph nodes had partially regressed, and the lesion of right parietal lobe had disappeared. The patient's clinical symptoms, such as blood-tinged sputum and dysphagia, had significantly improved.Lessons:We have described this case and reviewed the relevant literature concerning late distant recurrence of breast carcinoma. Importantly, this case indicates that patients with HR positive breast carcinoma are more likely to develop late distant recurrence and clinicians should not ignore the follow-up examinations even more than 20 years after the surgery.

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Section: Discussionmentioning

confidence: 99%

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

et al. 2018

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“…Intravitreal bevacizumab has been recently reported to be an optional treatment for choroidal metastasis when systemic chemotherapy and radiation therapy fail. 11 One of the contraindication of systemic bevacizumab is the development of necrotic hemorrhages which can cause uncontrolled hemoptysis. As best we know, there has not been any reports on the use of bevacizumab for a tumor with retinal hemorrhage, and it is not known if the tumor with massive retinal or vitreal hemorrhages can safely undergo intravitreous injections of bevacizumab.…”

Section: Discussionmentioning

confidence: 99%

Swept-source optical coherence tomographic findings in eyes with metastatic choroidal tumor

Ishida

Morohoshi

Takeuchi

et al. 2017

American Journal of Ophthalmology Case Reports

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PurposeTo report the swept-source optical coherence tomographic (OCT) findings in two eyes with choroidal metastases.ObservationsTwo patients with choroidal metastasis were studied. The metastasis was from a breast cancer in Case 1 and from a lung cancer in Case 2. In Case 1, swept-source OCT showed a highly reflective solid tumor with low optical reflective tissues that had replaced the choroidal tissue. Swept-source OCT was able to image the choroidal mass where other fundus imaging methods such as fluorescein angiography did not show the mass. Ophthalmoscopy of Case 2 showed hemorrhages in the inner retina, on the tumor, and in the vitreous. Swept-source OCT showed a subretinal mass with a steeple-crowned cap and a ruptured Bruch's membrane on the tumor.Conclusion and importanceSwept-source OCT imaging can detect the inner structure of a choroidal mass and retina around it in good detail.

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“…A number of studies have demonstrated the utility of conventional ultrasonography (B-mode and color Doppler) in the initial work-up of intraocular metastases (7,17). Differentiating malignant from benign iris masses relies primarily on topographic location, analysis of pattern and degree of vascularity.…”

Section: Discussionmentioning

confidence: 99%

“…There commended dose ranges from 1.25–4 mg, and it has proven to be a safe, effective and relatively easy local treatment for uveal metastasis (17,26–31). However, a number of patients with choroidal metastases originating from a variety of primaries, including the lung, colon and breast, experience progressive metastasis despite undergoing IVB treatment (32).…”

Section: Discussionmentioning

confidence: 99%

Iris metastasis as the first sign of small cell lung cancer: A case report

Liu

Nie

et al. 2017

Oncology Letters

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The current study documents an unusual case of iris metastasis as the first sign of small cell lung cancer (SCLC) and reviews the relevant literature to increase understanding and awareness of this rare condition. A 59-year-old male chronic smoker presented with a painful and red right eye without any disturbance of vision. The patient also complained of associated chronic cough and anorexia. Upon examination, an exfoliative, pinkish-white lesion of the right iris was observed. A systemic work-up was performed, which incidentally detected metastatic SCLC in the lower lobe of the right lung and was confirmed by histopathological examination. A thorough evaluation demonstrated no organ metastases, except in the iris. Following the failure of conservative approaches, the eye had to be enucleated. The clinical features, treatment and prognosis of this condition are briefly reviewed and the results of contrast-enhanced ultrasound (CEUS) examination observed in this case are presented. Despite their rarity, iris lesions should be considered as possible manifestations of underlying malignancies. Imaging techniques, particularly CEUS, may aid the detection, diagnosis and monitoring of such lesions.

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Treatment of ocular metastasis with anti-VEGF: A literature review and case report

Cited by 18 publications

References 22 publications

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

Swept-source optical coherence tomographic findings in eyes with metastatic choroidal tumor

Iris metastasis as the first sign of small cell lung cancer: A case report

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