Treatment of obesity with the resveratrol-enriched rice DJ-526

Abstract

Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4 μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

“…This is associated with activation of AMPK/SIRT1/PGC-1α pathway . Moreover, resveratrol might exhibit anti-obesity action by reducing the body weight and abdominal fat of experimental mice (Baek et al 2014). However, translation of these beneficial effects to the clinic has been difficult.…”

Epigenetics of Human Obesity: A Link Between Genetics and Nutrition

“…Dietary intervention on sulforaphane suggest an anti-obesity activity by inhibiting adipogenesis and suppressing lipogenesis [121]. An anti-obesity effect with reduction of body weight and abdominal obesity was also found in dietary intervention with resveratrol, present in red grapes [122], playing a role in epigenetic changes [123]. Soybean products are a good source of proteins that contains isoflavones, including genistein; data obtained in non-human primates showed epigenetic modifications associated with dietary interventions with soy protein that may potentially alter the risk of obesity [124].…”

Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue

“…Baek et al reported that resveratrol-enriched rice might treat obesity in high-fat diet fed mice . Our collaborative group reported that RR might act against metabolic syndrome and related diseases (Baek et al, 2013;Baek et al, 2014). Interestingly, RR shows synergistic effects in comparison that of each resveratrol or rice alone (Baek et al, 2013;Baek et al, 2014).…”

“…Our collaborative group reported that RR might act against metabolic syndrome and related diseases (Baek et al, 2013;Baek et al, 2014). Interestingly, RR shows synergistic effects in comparison that of each resveratrol or rice alone (Baek et al, 2013;Baek et al, 2014). Several reports show that resveratrol decreases the expression of tyrosinase (Franco et al, 2012;Zheng et al, 2012;Bae et al, 2013;Park and Boo, 2013;Park et al, 2014), and Jun et al reported that gamma-oryzanol from rice extract dually inhibited cellular melanogenesis, too (Jun et al, 2012).…”