“…There is little doubt, however, that some antibiotics do favourably modify the disease both strikingly and promptly. It is widely agreed that the tetracycline group falls into this category (Willcox, 1953(Willcox, , 1955Morton and Read, 1957;Doyle, Gill, and Laird, 1957;Csonka and Rosedale, 1962). In these circumstances we have felt it permissible to dispense with a comparable number of untreated controls.…”