Treatment Of Neonatal Renal Vein Thrombosis (RVT) With Urokinase (UK)

Abstract

The renal vein thrombosis represents an etiologic and therapeutic problem in neonatal pathology. In our milieu RVT is more frequent than is reported in current bibliography. This high incidence is accompanied by a high mortality and by the development of chronic renal failure among survivors.This fact led us to try a thrombolytic treatment that could be effective with respect to life and renal function.In our study we describe seven newborn patients with radiologically checked RVT. All cases were secondary to hypernatremic dehydration syndrome due to hyperconcentrated feeding. Five patients were submitted to thrombolytic treatment with UK, one patient was treated with heparin and one patient died before any treatment could be tried.Among the five patients treated with UK, four showed a complete recanalization of the RVT, with recovery of their renal function without sequelae. One of the patients, in whom an intracraneal haemorrhage was clinically suspected, died during treatment.The dosage of UK during treatment was 1000 U/Kg/hour.The duration of treatment was individualized according to renal evolution.The description of treated cases will be done individually.