Treatment of Negative Symptoms

Carpenter, William T.; Heinrichs, Douglas W.; Alphs, Larry

doi:10.1093/schbul/11.3.440

Cited by 469 publications

(198 citation statements)

References 89 publications

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“…Secondary negative symptoms are thought to result from other factors such as positive symptoms, depression and antipsychotics, while primary negative symptoms are linked to the disease process itself. [49][50][51] Corresponding to our findings, a specific association of apathy but not diminished expression with positive symptoms and depression has been proposed previously. 52 At the neural level, the observed positive correlation of apathy and increased VS activity contrasts with previous studies, including our own, reporting a negative association in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 88%

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Kirschner

Hager

Muff

et al. 2016

SCHBUL

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Striatal abnormalities play a crucial role in the pathophysiology of schizophrenia. Growing evidence suggests an association between aberrant striatal activity during reward anticipation and symptom dimensions in schizophrenia. However, it is not clear whether this holds across the psychosis continuum. The aim of the present study was to investigate alterations of ventral striatal activation during reward anticipation and its relationship to symptom expression in persons with schizotypal personality traits (SPT) and first-episode psychosis. Twenty-six individuals with high SPT, 26 patients with non-affective first-episode psychosis (including 13 with brief psychotic disorder (FEP-BPD) and 13 with first-episode schizophrenia [FEP-SZ]) and 25 healthy controls underwent event-related functional magnetic resonance imaging while performing a variant of the Monetary Incentive Delay task. Ventral striatal activation was positively correlated with total symptom severity, in particular with levels of positive symptoms. This association was observed across the psychosis continuum and within each subgroup. Patients with FEP-SZ showed the strongest elevation of striatal activation during reward anticipation, although symptom levels did not differ between groups in the psychosis continuum. While our results provide evidence that variance in striatal activation is mainly explained by dimensional symptom expression, patients with schizophrenia show an additional dysregulation of striatal activation. Trans-diagnostic approaches are promising in order to disentangle dimensional and categorical neural mechanisms in the psychosis continuum.

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Section: Discussionsupporting

confidence: 88%

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Kirschner

Hager

Muff

et al. 2016

SCHBUL

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“…As reviewed in detail elsewhere [315], dually diagnosed schizophrenia patients typically present with more severe symptoms [308,309,[316][317][318][319], exhibit increased suicidal ideation [320,321], require more frequent hospitalizations [310,322], and experience more frequent relapses than patients without co-occurring substance abuse [323][324][325]. While analyses for polymorphisms in the Homer genes have not yet been assessed in a co-morbid population, single nucleotide polymorphisms in Homer1 have been associated with cocaine addiction [241], as well as in schizophrenia (IVS4 + 18A > G in intron 4) [326].…”

Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

159

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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“…Para estratégias terapêuticas futuras, é importante diferenciar a sintomatologia negativa em: sintomas negativos primários; sintomas negativos secundários (em conseqüência dos sintomas positivos, como o afastamento social por causa de idéias paranóides); decorrentes de SEP (como acinesia induzida por neuroléptico); sintomas depressivos (como depressão pós-psicótica ou farmacogênica); ou fatores ambientais (como falta de estimulação social decorrente de hospitalização) (Carpenter et al, 1985). O tratamento da esquizofrenia com predomínio de sintomas negativos já foi descrito em outras fontes (ver parte 1 destas diretrizes; Falkai et al, 2005).…”

Section: Considerações Especiais No Tratamento De Longo Prazo Sintomaunclassified

Diretrizes da Federação Mundial das Sociedades de Psiquiatria Biológica para o tratamento biológico da esquizofrenia. Parte 2: tratamento de longo prazo

Falkai¹,

Wobrock²,

Lieberman³

et al. 2006

Rev. psiquiatr. clín.

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ResumoEstas diretrizes para o tratamento biológico da esquizofrenia foram desenvolvidas pela Força-Tarefa da Federação Mundial das Sociedades de Psiquiatria Biológica (World Federation of Societies of Biological Psychiatry, WFSBP). As metas fixadas durante o desenvolvimento destas diretrizes foi a revisão sistemática de todas as evidências disponíveis referentes ao tratamento da esquizofrenia, tanto no âmbito clínico como no científico, e o estabelecimento de um consenso sobre as principais recomendações para a prática psiquiátrica. Estas diretrizes são destinadas a todos os médicos que atendem e tratam de pacientes portadores de esquizofrenia. Os dados usados para desenvolver estas diretrizes foram extraídos primariamente de vários painéis e diretrizes nacionais para o tratamento da esquizofrenia, assim como de metanálises, revisões e estudos clínicos randomizados sobre a eficácia do tratamento farmacológico e de outras intervenções terapêuticas biológicas, identificadas por uma busca nas bases de dados MedLine e na Biblioteca Cochrane. A literatura identificada

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Treatment of Negative Symptoms

Cited by 469 publications

References 89 publications

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Homers regulate drug-induced neuroplasticity: Implications for addiction

Diretrizes da Federação Mundial das Sociedades de Psiquiatria Biológica para o tratamento biológico da esquizofrenia. Parte 2: tratamento de longo prazo

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