Treatment of Nail Bed Defects with Hard Palate Mucosal Grafts

Fernández-Mejía, Silvia; Domínguez‐Cherit, Judith; Pichardo-Velázquez, Patricia; González-Olvera, Sergio

doi:10.2310/7750.2006.00020

Cited by 12 publications

(11 citation statements)

References 6 publications

(12 reference statements)

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“…Although not often stated explicitly, the reviewed articles suggest that the primary surgeon, especially in the case of otolaryngologists, was the one performing the oral graft harvesting. Reports of interdisciplinary approaches are limited; one dermatologic application stated that, in support of the dermatologist, the oral graft harvesting was performed by an otolaryngologist 50 . The apparent lack of engagement of periodontists suggests there is untapped potential for collaboration between periodontal and medical specialists for the benefit of patients in need of such procedures.…”

Section: Discussionmentioning

confidence: 99%

Extraoral Uses of Autologous Oral Soft Tissue Grafts: A Different Bridge Between Mouth and Body Health

Gordon

Parashis

Tatakis

2017

Clin Adv Periodontics

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Focused Clinical Question: Are there any extraoral uses for intraoral soft tissue grafts? Summary: Despite extensive literature on the intraoral uses of soft tissue autografts harvested from oral sites, the periodontal literature is lacking information on the extraoral uses of such grafts. The purpose of this article is to review the autologous use of certain oral soft tissue grafts for extraoral indications. A literature search revealed that several medical specialties, including otolaryngology, ophthalmology, dermatology, plastic surgery, and urology, have a track record of positive outcomes with the use of free gingival, buccal fat pad, and buccal mucosa grafts for a wide variety of reconstructive procedures at diverse body sites. Conclusions: The numerous successful extraoral uses of oral soft tissue autografts underscore the versatility of these tissues in reconstructive surgery and suggest there is potential for collaboration between periodontal and medical specialists for the benefit of patients in need of such reconstructions. Broader awareness of these applications of oral soft tissue grafts could help expand their current uses and would allow practitioners to better answer possible patient inquiries.

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Section: Discussionmentioning

confidence: 99%

Extraoral Uses of Autologous Oral Soft Tissue Grafts: A Different Bridge Between Mouth and Body Health

Gordon

Parashis

Tatakis

2017

Clin Adv Periodontics

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“…In case of nail bed defect associated with the distal phalanx exposure, a local V‐Y advancement flap is needed (Hwang, Park, Song, Jung, & Kim, ). Fernandez‐Mejia, Dominguez‐Cherit, Pichardo‐Velazquez, and Gonzalez‐Olvera () applied different kinds of skin flaps and hard palate mucosal grafts to recover nail bed defects after resecting subungual exostoses. These reconstruction methods are frequently used and provide cosmetic benefits.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, the area of nail bed defects is managed by replacing it with a split thickness nail bed graft, which is harvested from the adjacent nail bed when the defect is very small or from the great toe nail when the defect is large. In case of nail bed defect associated with the distal phalanx exposure, a local V-Y advancement flap is needed (Hwang, Park, Song, Jung, & Kim, 2013 and Gonzalez-Olvera (2006) applied different kinds of skin flaps and hard palate mucosal grafts to recover nail bed defects after resecting subungual exostoses. These reconstruction methods are frequently used and provide cosmetic benefits.…”

Section: Introductionmentioning

confidence: 99%

Human nail bed‐derived decellularized scaffold regulates mesenchymal stem cells for nail plate regeneration

Cui

Zhang

et al. 2019

J Tissue Eng Regen Med

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Among hand trauma, nail bed is the most involved tissue in hospital emergency departments, resulting in the loss of nail plate, which leads to a disturbance of hand grasp function, long‐lasting digit tip pain, hyperpathia, and disesthesia. Treatment of nail bed defects is a significant clinical challenge due to the lack of uniform nail bed thickness and distinct regenerative ability. In this study, it is shown that the extracellular matrix of decellularized nail bed scaffolds can play an important role in inducing bone mesenchymal stem cells to differentiate into nail epithelial cells. Using decellularized nail bed scaffolds combined with bone mesenchymal stem cells, it is revealed that the engineered nail bed can promote nude mouse nail plate regeneration ectopically. The natural extracellular matrix of decellularized nail bed scaffolds can serve as a 3D structural template for bone mesenchymal stem cell differentiation into nail‐associated cells, initiating the nail plate regeneration. These results not only provide a proof‐of‐principle for the generation of transplantable nail grafts based on decellularized nail bed scaffolds derived from clinically wasted amputated fingers but also provide important considerations for clinical treatment for digit tip trauma.

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“…It supports the nail plate, of which it forms 20%, but it does not regenerate itself (1). Nail dystrophy occurs secondary to nail trauma or treatment of subungal tumors (2). Open treatment is one of the simplest and least invasive methods for closing such nail bed defects.…”

Section: Introductionmentioning

confidence: 99%

Nail bed defect covered with labial mucosa graft after subungal glomus tumor removal

et al. 2013

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The nail bed is an important part of the nail unit. It supports the nail plate, but does not regenerate itself. The labial mucosa and the nail bed both lack a granular layer. Because the keratinization of the nail bed can cause poor nail adhesion, harvesting graft from nonkeratinized sites is preferred. Furthermore, harvesting graft from labial mucosa is convenient in surgical approach. Therefore, the labial mucosa is more eligible for covering the nail bed defect than other graft methods. In this report, a 46-year-old female patient suffered from a subungal glomus tumor of the right fourth fingernail bed for 10 years. After the nail plate was removed, complete excision of the tumor was performed, and a labial mucosa graft was used to cover the defect. Eight months after the operation, the tumor had not reoccurred and no nail deformity was observed. This outcome demonstrates that our procedure is a good surgical option for treatment of nail bed defects.

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Treatment of Nail Bed Defects with Hard Palate Mucosal Grafts

Abstract: This is a relatively easy procedure for experienced surgeons to correct nail dystrophy secondary to a nail bed scar, with good to excellent results.

Cited by 12 publications

References 6 publications

Extraoral Uses of Autologous Oral Soft Tissue Grafts: A Different Bridge Between Mouth and Body Health

Extraoral Uses of Autologous Oral Soft Tissue Grafts: A Different Bridge Between Mouth and Body Health

Human nail bed‐derived decellularized scaffold regulates mesenchymal stem cells for nail plate regeneration

Nail bed defect covered with labial mucosa graft after subungal glomus tumor removal

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