Treatment of myeloid sarcoma without bone marrow involvement with gemtuzumab ozogamicin-containing regimen

Gastrointestinal Myeloid Sarcoma a Case Presentation and Critical Review of the Literature

“…1,35 Remission-type induction chemotherapy regimens have also been used in isolated myeloid sarcoma, demonstrating a decrease in the rate of progression and an increase in overall survival. 35,36 The role of hematopoietic stem cell transplantation (HSCT) following induction therapy is supported by retrospective studies, which indicate that allogeneic HSCT is associated with a 5-year overall survival rate of 48% and leukemia-free survival of 36%. 37 Localized radiation therapy (RT) has also been considered as consolidation treatment for isolated MS. 38 Systemic treatment is the first-line option for myeloid sarcoma with concurrent marrow involvement at diagnosis.…”

“…For example, the humanized anti-CD33 monoclonal antibody has been associated with good responses. 35,36 In addition, tyrosine kinase inhibitors have also shown promising results in a patient with myeloid sarcoma associated with FIP1L1-PDGFRA fusion gene and eosinophilia. 42 Conclusions.…”