Treatment of Myasthenia Gravis With Physostigmine

Walker, M.B.

doi:10.1016/s0140-6736(00)94294-6

Cited by 306 publications

(87 citation statements)

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“…One such is the miracle at St Alfege's Hospital Greenwich, London, as described by Mary Broadfoot Walker in her letter to the Lancet in 1934. 1 First, to set the context: myasthenia gravis was at that time an incurable progressive neurological illness that resulted in double vision, muscular weakness, difficulty in swallowing and eventually respiratory paralysis. Walker reported a rapid response to physostigmine: 1 'Several comments can be made about this patient's reponse to physostigmine:…”

mentioning

confidence: 99%

The miracle at St Alfege's: seventy years on

Lee¹

2007

Journal of the Royal Society of Medicine

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confidence: 99%

The miracle at St Alfege's: seventy years on

Lee¹

2007

Journal of the Royal Society of Medicine

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“…AcChoR from embryonic rats was indistinguishable immunologically from EJR of adult muscle. Myasthenia gravis is an autoimmune disease characterized by muscle weakness and rapidly fatiguing neuromuscular transmission (1,2). These symptoms are probably due to a reduced number of acetylcholine receptors (AcChoR) at the neuromuscular junction (3).…”

mentioning

confidence: 99%

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

Weinberg¹,

Hall²

1979

Proc. Natl. Acad. Sci. U.S.A.

122

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We have examined the interaction between sera from patients with myasthenia gravis and acetylcholine receptor (AcChoR) purified from normal and denervated rat skeletal muscles [junctional receptor (UR) and extrajunctional receptor (EJR), respectively]. Eight of ten myasthenic sera had titers against EJR that were significantly higher (1.1-2.4 times) than their titers against JR. The antireceptor titers of these sera ranged from 2 to 102 nM. Although activities of three other sera were too low (<1 nM) to allow accurate titrations, provisional measurements with these sera gave titers against EJR that were at least as high (1.0-1.4 times) as those against JR. Competition

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“…Table The In addition to physostigmine, Dr. Mary Walker also studied the effects of neostigmine and potassium chloride on MG patients with remarkable yet short-lasting results. She noted an improvement in muscle fatigue and the absence of central side effects of physostigmine (18,30).…”

Section: The Miracle Of St Alfege's Hospital: Physostigminementioning

confidence: 99%

The miracle of St. Alfege’s Hospital and the history of the treatment of myasthenia gravis

Croitoru¹,

Turliuc²,

Danciu³

et al. 2017

Romanian Neurosurgery

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Abstract:Having a recent history, the neurological condition called myasthenia gravis has raised dilemmas and questions among doctors since it was first discovered in the 16th century and it has not ceased to be a challenge. Nowadays, neuroscience researchers from around the world have been striving to perfect a modern treatment of this condition. Our paper is an incursion into the past, more precisely into the history of the treatment of this disease, from its origin to date, when immunological therapy has progressed.

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Treatment of Myasthenia Gravis With Physostigmine

Cited by 306 publications

References 0 publications

The miracle at St Alfege's: seventy years on

The miracle at St Alfege's: seventy years on

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

The miracle of St. Alfege’s Hospital and the history of the treatment of myasthenia gravis

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