Treatment of Migraine Attacks: A Comparative Study

Clinical and Experimental Evaluation of a New Ergot‐derivative (Ergostine) in the Treatment of Migraine

“…The values do not differ from those obtained in migraine attacks treated wiht 1 mg ergotamine intramuscularly, or from those published by us previously 10 . The values do not differ from those obtained in migraine attacks treated wiht 1 mg ergotamine intramuscularly, or from those published by us previously 10 .…”

“….36 mm, is highly significant. The values do not differ from those obtained in migraine attacks treated wiht 1 mg ergotamine intramuscularly, or from those published by us previously10 . The pulse amplitude of the A. radialis was not afffected by the ergostine treatment.…”

“…The vasoconstrictor effect is fully preserved. Finally, ergotamine was significantly better tolerated when its side-effects have been at least partially prevented by the administration of muscle relaxants (meprobamate) and antiemetics, such as chlorcyclizine 10 . According to A. Cerletti and B. Berde the vasoconstrictor effect of both compounds, as measured in spinal cats, is identical.…”

“…Thus, the addition of caffeine renders ergot compounds effective, when administered perorally or rectally. Finally, ergotamine was significantly better tolerated when its side-effects have been at least partially prevented by the administration of muscle relaxants (meprobamate) and antiemetics, such as chlorcyclizine 10 . In double blind trials (unpublished) we have shown conclusively that 9-(N-methyl pi-peridyden 4') thioxanthen, called 'BP 400 Sandoz', is most effective in preventing nausea and vomiting in combination with ergotamine.…”