Treatment of Metastatic Hypernephroma

Talley, Robert W.

doi:10.1001/jama.1969.03150150034007

Cited by 65 publications

(10 citation statements)

References 10 publications

(1 reference statement)

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“…Of the 12 long term survivors in their series, nine underwent excision of metastasis more than 4 years after nephrectomy. Jett et al [14] considered 18 months and Talley et al [16] 24 [4,61.…”

Section: Discussionmentioning

confidence: 99%

Solitary metastases from renal cell carcinoma: A review

Tongaonkar

Kulkarni

Kamat

1992

Journal of Surgical Oncology

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Nineteen patients with solitary metastatic lesions from renal cell carcinoma, 5 synchronous and 14 metachronous, were seen at the Tata Memorial Hospital over a 7 year period between 1981 and 1987. The mean metastatic interval for the metachronous lesions was 31.2 months. The commonest sites of metastases were bone, lung, and liver. The solitary nature of the metastasis was confirmed by appropriate investigations. All patients underwent nephrectomy for the primary kidney lesion. The metastatic lesions were treated with intent of cure. Only 1 patient with synchronous metastasis survived for 2 years and none survived 5 years while in the metachronous metastasis group, the estimated overall survival was 50% at 2 years and 25% at 5 years. The patients with a long metastasis-free interval were found to have a better survival. The patients with liver metastasis did poorly as compared to those with metastases at other sites. The stage of the disease also had a bearing on the survival.

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Section: Discussionmentioning

confidence: 99%

Solitary metastases from renal cell carcinoma: A review

Tongaonkar

Kulkarni

Kamat

1992

Journal of Surgical Oncology

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“…Massive bleeding can occur in the case of infiltrative lesions, and it is advisable to have cross-matched blood available. We think that permanent postoperative hypocalcemia can be avoided by parathyroid transplantation (Wells et al, 1979). The complications to surgery can to a great extent be avoided by meticulous technique and, therefore, we advocate an aggressive surgical approach to these thyroid lesions, including total or near-total thyroidectomy.…”

Section: Survivalmentioning

confidence: 99%

“…Talley et al (1969) showed that a tumor-free interval of 18 months or more was associated with a significantly longer survival. In most reports on thyroid secondaries, the tumor-free interval is long, as summerized by Friberg and Kinnman (1969).…”

Section: Survivalmentioning

confidence: 99%

Surgical treatment of metastatic disease in the thyroid gland

Ericsson

Biörklund

Cederquist

et al. 1981

Journal of Surgical Oncology

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Metastatic disease in the thyroid gland is uncommon in clinical practice. Preoperative investigation with thyroid scan and fine-needle aspiration biopsy verified or strongly suggested metastatic disease in seven out of nine patients. All patients were treated by thyroid surgery. Three patients died within 4 months in disseminated disease. The remaining seven patients had a survival rate of between 1 and 5 years. Three patients are still alive 12, 29, and 48 months after thyroid surgery. Surgical treatment for metastatic disease in the thyroid, especially due to metastatic renal carcinoma and melanoma, is recommended.

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“…The occasionally witnessed benefit from progestin therapy in patients suf fering from advanced renal cell carcinoma, in conjunction with the well-known resistance o f this tumour to radiotherapy (6,11,13) and various chemothera peutic manoeuvres (6,11), has led to the continued use o f progestational compounds in the treatment of this relentless disease.…”

Section: Introductionmentioning

confidence: 99%

The Endocrine Background of Human Renal Cell Carcinoma

1979

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Cytosol preparations obtained from 9 different human renal cell carcinomas were investigated for the eventual presence of progestin-binding inhibitors which might offer an explanation for the previous failure to demonstrate high receptor levels in the tumour tissue. The inhibitory potency of these preparations was estimated by measuring the decrease of R 5020 binding to uterine progestin receptors in the presence of tumour cytosol. Interestingly, cytosol from human renal cell carcinoma was found to contain progestin-binding inhibitors. The average inhibition of R-5020-receptor interaction amounted to 46%. In only 1 out of 9 cases, binding was completely suppressed. In order to circumvent the inhibitory reaction potentially occurring in cell-free systems, R-5020-binding studies additionally were performed in cell suspension. Out of 7 carcinomas studied using this assay system, 5 did not contain any specific progestin-binding entities. In 1 tumour, receptor-atypical non-saturable binding was observed. Only in isolated cells prepared from 1 other carcinoma, could slight indications for the presence of low concentrations of progestin receptors be detected.

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Treatment of Metastatic Hypernephroma

Cited by 65 publications

References 10 publications

Solitary metastases from renal cell carcinoma: A review

Solitary metastases from renal cell carcinoma: A review

Surgical treatment of metastatic disease in the thyroid gland

The Endocrine Background of Human Renal Cell Carcinoma

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