Treatment of metastatic breast cancer with a combination of adrenalectomy and 5-fluorouracilProgress report

Follow-up study of left suprarenal to inferior mesenteric venous shunt for advanced breast cancer

“…24.2 months by MacDonald (1962), 28.8 months by Yonemoto et al (1967) and 36.3 months by Barlow and Meggitt (1968). The results of the type of major endocrine ablation described here are similar to those reported in total adrenalectomized patients for some prognostic factors such as menopausal status or age of the patients, disease-free interval and main sites of metastases (Delarue et al, 1967;Barlow and Meggitt, 1968;Harris and Spratt, 1969;Horsley et al, 1971;Schmidt et al, 1971 ;Wilson et al, 1971).…”

“…The use of chemotherapeutic agents such as 5-fluorouracil, cyclophosphamide or Mitomycin C in adrenalectomized or oophorectomized patients results in an elevation of the objective response rate of the ablation surgery (Horsley et al, 1971;van Dyk and Falkson, 1971 ;Wilson et al, 1971). The usefulness of the combined procedure (endocrine ablation plus chemotherapy) has been reported in the DMBAinduced rat mammary tumour (Nomura et al, 1971).…”

Cancer of the Breast: Forward Look in the 1970s

“…One of these compounds (ergocryptine) has been used in the treatment of breast cancer patients but with no result (EORTC Breast Cancer Group 1972a). Some improvement has been reported in the overall response rate from adrenalectomy by the simultaneous use of 5-fluorouracil (Wilson et al 1972). The combination of treatments seems to be of particular value in patients with a short free interval and with visceral disease.…”

Λεμφαγγειακαι Μεταστασεις Πνευμονος Εκ Καρκινου Του Μαστου Και Η Δια Συνδεδυασμενης Χημειοθεραπειας Αντιμετωπισις Των

“…Οί Wilson καί συνεργάται 170 τό 1971 άνεκοίνωσαν τα αποτελέσματα των επί γενικευμένου καρκίνου του μαστοΰ, όστις περιελάμβανε καί λεμφαγγειακάς μεταστάσεις πνεύμονος, δια συνδυασμού έπινεφριδιεκτομής καί 5 -FU.…”