Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors

Vollmer, Günter; Papke, Anja; Zierau, Oliver

doi:10.1186/1749-8546-5-7

Cited by 13 publications

(15 citation statements)

References 32 publications

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“…An extended in vivo study for 90 days with ovariectomized rats also confirmed that the rhubarb extract did not induce uterotrophy or markers of proliferation, while it showed no effect on the bone mineral density [128]. Vollmer et al [129] also reported that different doses of the rhubarb extract did not enhance the uterine wet weight and the proliferation marker genes in ovariectomized rats. Interestingly, when the extract was combined with E 2 , it counteracted the uterotrophic effects of E 2 , dose-dependently [129].…”

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confidence: 84%

“…Vollmer et al [129] also reported that different doses of the rhubarb extract did not enhance the uterine wet weight and the proliferation marker genes in ovariectomized rats. Interestingly, when the extract was combined with E 2 , it counteracted the uterotrophic effects of E 2 , dose-dependently [129]. They reported that the two compounds, trans-rhapontigenin and desoxyrhapontigenin (l " Table 1, Fig.…”

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confidence: 97%

“…However, Vieira et al [69] showed that different commercially available soy supplements increased uterine weight in immature female rats when applied at increasing serial doses (125-4150 mg/kg/day) for 3 days. The [124,129,138,189], radiometric binding assay in cells or tissues [113,187,188,190], inhibition ELISA using purified human ER [186], and dextran-coated charcoal method in cells [89]. b Some compounds might not be plant-specific.…”

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confidence: 99%

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Botanical Modulation of Menopausal Symptoms: Mechanisms of Action?

2013

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Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats which can affect quality of life. Although hormone therapy (HT) has been the treatment of choice for relieving these symptoms, HT has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief, have been controversial and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways. Plant extracts with potential estrogenic activities include soy, red clover, kudzu, hops, licorice, rhubarb, yam, and chasteberry. Botanicals with reported progestogenic activities are red clover, hops, yam, and chasteberry. Serotonergic mechanisms have also been proposed since women taking antidepressants often report reduction in hot flashes and night sweats. Black cohosh, kudzu, kava, licorice, and dong quai all either have reported 5-HT7 ligands or inhibit serotonin re-uptake, therefore have potential serotonergic activities. Understanding the mechanisms of action of these natural remedies used for women’s health, could lead to more efficacious formulations and to the isolation of active components which have the potential of becoming effective medications in the future.

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Botanical Modulation of Menopausal Symptoms: Mechanisms of Action?

2013

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“…However, the most abundant constituents represent less active forms and are assumed to be metabolically acti vated (31). The estrogenic activity of the Rheum rhaponticum extract ERr 731 or its phytoestrogen rhapontigenin has been investigated by reporter gene assays as well as ligand binding assays demonstra ting cell specific ER α activity in U2OS bone cells and ER β activity in endometrium adenocarcinoma cells (HEC-1B) (32). In ovarectomized rats it did, however, not induce proliferation of endometrium cells or related gene activity.…”

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confidence: 99%

Influence of Rheum rhaponticum, Cimicifuga racemosa and Trifolium pratense extracts on breast cancer cell proliferation

Gründemann¹,

Hertrampf²,

Sauer³

et al. 2015

Z Phytother

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Summary Background: Extracts from the Siberian rhubarb (Rheum rhaponticum) as well as those from red clover (Trifolium pratense) contain phytoestrogens, while black cohosh (Cimicifuga racemosa) may alternatively modify estrogen receptor activity. They have been used for the treatment of menopausal symptoms. Little is known about their effects on estrogen-dependent tumor cells. Materials and Methods: The influence of a standardized preparation of Rheum rhaponticum (ERr 731?), a well described preparation of Trifolium pratense (Menoflavon? extra) and a commercial preparation of Cimicifuga racemosa (Cefakliman? mono) on proliferation of breast cancer cells was analyzed by the crystal violet assay in estrogen-receptor (ER) dependent (MCF-7) and ER independent (MDA-MB-231) cell-based systems. As positive control for the proliferation of MCF-7 cells we used 17 ?-estradiol. The estrogen specificity was demonstrated by applying the ER antagonist ICI182,780 to the cell culture. Results: Rheum rhaponticum and Cimicifuga racemosa did not induce cell proliferation of MCF-7 or MDA-MB-231 cells. High concentration (100 ?g/mL) of Rheum rhaponticum and Trifolium pratense extract were toxic to both cell lines. Trifolium pratense slightly increased proliferation of MCF-7 cells in a dose dependent manner, but this effect was not estrogen specific. Conclusion: Our results demonstrate that the used extracts have no estrogen specific impact on the proliferation of ER dependent and ER independent breast cancer cells.

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“…The effects of rhubarb extracts on experimental chronic renal failure (CRF) indicate that it can reduce proteinuria and the severity glomerulosclerosis within remnant kidneys in rats [29]. Treatment of menopausal symptoms using an extract from the roots of Rhapontic rhubarb (plus the results of in vitro and in vivo experiments) indicate estrogenic actions, especially estrogen receptor b (ERb)-mediated effects [30]. Oligostilbenes from rhubarb also inhibit low-density lipoprotein and highdensity lipoprotein oxidation humans [31], suggesting a pivotal role in the prevention of lipoprotein oxidation.…”

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confidence: 99%

Anticancer potential of emodin

2012

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Keywords: angiogenesis apoptosis cell cycle arrest emodin traditional Chinese medicine (TCM) a b s t r a c t Traditional Chinese Medicine (TCM) is widely used in clinical research due to its low toxicity, low number of side effects, and low cost. Many components of common fruits and vegetables play well-documented roles as chemopreventive or chemotherapeutic agents that suppress tumorigenesis. Anthraquinones are commonly extracted from the Polygonaceae family of plants, e.g., Rheum palmatum and Rheum officinale. Some of the major chemical components of anthraquinone and its derivatives, such as aloe-emodin, danthron, emodin, chrysophanol, physcion, and rhein, have demonstrated potential anticancer properties. This review evaluates the pharmacological effects of emodin, a major component of Aloe vera. In particular, emodin demonstrates anti-neoplastic, anti-inflammatory, anti-angiogenesis, and toxicological potential for use in pharmacology, both in vitro and in vivo. Emodin demonstrates cytotoxic effects (e.g., cell death) through the arrest of the cell cycle and the induction of apoptosis in cancer cells. The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1a, glutathione S-transferase P, N-acetyltransferase,and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells. Hopefully, this summary will provide information regarding the actions of emodin in cancer cells and broaden the application potential of chemotherapy to additional cancer patients in the future.

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Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors

Cited by 13 publications

References 32 publications

Botanical Modulation of Menopausal Symptoms: Mechanisms of Action?

Botanical Modulation of Menopausal Symptoms: Mechanisms of Action?

Influence of Rheum rhaponticum, Cimicifuga racemosa and Trifolium pratense extracts on breast cancer cell proliferation

Anticancer potential of emodin

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