Treatment of medication-overuse headache: A systematic review

Chiang, Chia‐Chun; Schwedt, Todd J.; Wang, Shuu Jiun; Dodick, David W.

doi:10.1177/0333102415593088

Cited by 164 publications

(180 citation statements)

References 94 publications

(314 reference statements)

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“…Currently, there is a global trend in chronification of migraine and a growing number of cases of medication overuse headache due to improper use and/or overuse of painkillers23. Interestingly, medication overuse headache could develop not only due to overuse of opioids but even after ‘specific’ anti-migraine treatments with triptans4.…”

mentioning

confidence: 99%

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Virtanen

Giniatullin

Mäntyselkä

et al. 2017

Sci Rep

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Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.

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mentioning

confidence: 99%

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Virtanen

Giniatullin

Mäntyselkä

et al. 2017

Sci Rep

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“…The outcome was even better after complete discontinuation than low-dose caffeine consumption. Taken together, our study results might indicate that migraine patients may benefit from complete abstinence of caffeine, similarly to the abrupt discontinuation of acute analgesics for detoxification in patients with medication overuse headache [20, 21]. …”

Section: Discussionmentioning

confidence: 90%

Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study

Lee

Choi

et al. 2016

J Headache Pain

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BackgroundCaffeine has both excitatory and vasoconstrictive effects on central nervous system. Caffeine use might be associated with development and chronification of migraine. We aimed to evaluate the effect of caffeine cessation on the acute treatment of migraine.MethodsWe prospectively recruited migraine patients who consumed caffeine drinks daily and instructed them to discontinue their caffeine intake. Triptans were prescribed for acute treatment. Patients were followed up after at least two weeks after screening and evaluated the efficacy of acute treatment with the migraine assessment of current therapy (Migraine-ACT) questionnaire. Excellent efficacy was defined as Migraine-ACT score of 4. Chronic migraine, body mass index, allodynia, depression, anxiety, antiemetic use, and use of prophylactic medication were included in the multivariate analysis if the univariate p < 0.2.FindingsAmong 108 patients included, 36 completely discontinued their caffeine intake (abstinence group). The efficacy of acute treatment was assessed at median 34.5 days (interquartile range, 28–89) after the screening. Twenty-six patients (72.2 %) in the abstinence group and 29 (40.3 %) in the non-abstinence group reported an excellent efficacy (p = 0.002). The abstinence group also showed a trend toward greater reduction of headache impact test-6 (HIT-6) scores (p = 0.085). Caffeine abstinence was independently associated with an excellent efficacy of acute treatment (multivariate odds ratio, 3.2; 95 % confidence interval, 1.2–8.4; p = 0.018) after controlling for covariates.ConclusionsCaffeine abstinence is associated with better efficacy of acute migraine treatment. Our uncontrolled study results encourage a further confirmatory study on this issue.

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“…Several other (systematic) reviews have been published evaluating the effectiveness of treatments for patients with MOH [4,13,16,21]. All reviews included studies with varying designs, including patient series and cohort studies.…”

Section: Comparison With Other Literaturementioning

confidence: 99%

The Effectiveness of Treatments for Patients With Medication Overuse Headache: A Systematic Review and Meta-Analysis

Goffau

Klaver

Willemsen

et al. 2017

The Journal of Pain

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Treatment of medication-overuse headache: A systematic review

Cited by 164 publications

References 94 publications

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study

The Effectiveness of Treatments for Patients With Medication Overuse Headache: A Systematic Review and Meta-Analysis

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