Treatment of Maternal Hypergalactia

Eglash, Anne

doi:10.1089/bfm.2014.0133

Cited by 18 publications

(37 citation statements)

References 16 publications

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“…4 In addition, the prevalence of oversupply is unclear because of a lack of diagnostic criteria and research on the topic. Most define oversupply as milk production in excess of that needed for normal growth of the infant.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Most define oversupply as milk production in excess of that needed for normal growth of the infant. 4 Other terms for this include hypergalactia or hyperlactation. The term galactorrhea is usually applied only to nonlactating women or men.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…14 Excessive pumping, overuse of galactogogues, and overstimulation by the baby may also result in oversupply 4 ( Table 2).…”

Section: Differential Diagnosismentioning

confidence: 99%

“…16 Block feedings are also recommended (strength of recommendation, C). 4,7 In these the mother nurses from a single breast for a block of time, typically 3 hours. She then alternates breasts for successive blocks.…”

Section: Managementmentioning

confidence: 99%

“…In this way milk accumulates in the unused breast and should decrease milk supply. 4,7 van Veldhuizen-Staas 7 reports that the complete drainage of both breasts before beginning the block feedings reduces the excess milk supply and thereby reduces the mother's engorgement and the infant's difficulties feeding with an overactive milk flow (level of evidence, 3). Use of a nipple shield may help slow the flow of milk for the infant and decrease distress during an overactive let-down.…”

Section: Managementmentioning

confidence: 99%

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Diagnosis and Management of Breast Milk Oversupply

Trimeloni

Spencer

2016

The Journal of the American Board of Family Medicine

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

“…14 Excessive pumping, overuse of galactogogues, and overstimulation by the baby may also result in oversupply 4 ( Table 2).…”

Section: Differential Diagnosismentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

See 3 more Smart Citations

Diagnosis and Management of Breast Milk Oversupply

Trimeloni

Spencer

2016

The Journal of the American Board of Family Medicine

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Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro

Suzuki

Tsugami

Wakasa

et al. 2020

Molecular Nutrition Food Res

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Scope: Peppermint is traditionally used as an antigalactagogue in breastfeeding women. However, the suppressive mechanism remains unclear. The authors investigate whether and how peppermint influences milk production at the cellular and molecular levels. Methods and Results: A lactating mammary epithelial cell (MEC) culture model that produces major milk components is prepared. Peppermint oil (PMO) suppresses-casein production in conjunction with the induced enlargement of cytoplasmic lipid droplets (CLDs). PMO also significantly inactivates STAT5 and mTOR in the lactogenic signaling pathway. Menthol treatment, which is a primary PMO component, leads to decreases in-casein production, enlarged CLDs, the inactivated STAT5 and mTOR. Eucalyptol and menthyl acetate, other components of peppermint, does not show suppressive effects on lactating MECs. The inactivation of STAT5 and mTOR upon menthol administration is also evident in alveolar MECs of lactating mice. Furthermore, lactating MECs expresses TRPM8 and TRPA1, which are menthol receptors known as cold receptors. Agonists of TRPM8 and TRPA1 suppresses-casein production and inactivation of STAT5 and mTOR in the lactating MECs. Conclusion: These findings indicate that peppermint has potential as an antigalactagogue. Menthol is suggested to be an active compound in peppermint. TRPM8 and TRPA1 may function as receptors for menthol.

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Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

Kelleher,

Burkinshaw,

Kuyooro

2024

Molecular Nutrition Food Res

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Botanicals and herbal supplements contain a diverse array of polyphenols that may affect mammary gland function and promote galactagogue activity. This scoping review is conducted to identify scientific literature elucidating how polyphenols affect mammary gland biology and cellular mechanisms critical for lactation. A literature search of PubMed and Medline reviews relevant studies in dairy animals, rodent models, and cultured mammary epithelial cells that are published from January 2010 until July 2023, to ascertain effects of polyphenols on mechanisms regulating milk production and composition. The PRISMA‐ScR (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses for Scoping Review) strategy is applied and 80 studies on polyphenols and their implications on milk production and composition are included in this review. Limited information delineating effects of polyphenols on the molecular pathways that affect lactation are found, although available information suggests modulation of Stat5 signaling/differentiation, Stat3 signaling/remodeling, mTOR and insulin signaling/energy production, and nuclear factor kappa beta (NFκβ) signaling/oxidative stress and inflammation may play roles. A profound lack of mechanistic information underscores the critical need for further research to understand the impact of botanical supplements and polyphenols on milk production and composition in humans to establish maternal nutritional guidelines to support lactation and breastfeeding goals.

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Treatment of Maternal Hypergalactia

Cited by 18 publications

References 16 publications

Diagnosis and Management of Breast Milk Oversupply

Diagnosis and Management of Breast Milk Oversupply

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

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