Treatment of Manic Illness with Lithium Carbonate

Maggs, Ronald

doi:10.1192/bjp.109.458.56

Cited by 201 publications

(40 citation statements)

References 15 publications

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“…As Maggs has pointed out (14), in or der to say that the treatment has been effective it must be possible to deduce that the intensity and/or duration of the individual illness has lessened or that the interval between individual attacks has increased. Contrary to the findings of Baastrup and Schou (1), who reported the latter, we did not find an increase in the duration between individual attacks in the group with periodic disorders.…”

Section: Resultsmentioning

confidence: 99%

A Longitudinal Investigation of Lithium as a Prophylactic Agent for Recurrent Depressions

1970

Canadian Psychiatric Association Journal

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Twenty-one patients with recurrent endogenous depressions were treated with lithium carbonate for periods up to two and a half years. Although depressions did not recur in six of eight patients with non-periodic disorders who were on lithium, the treatment did not reduce the frequency of exacerbation in eleven of thirteen periodic disorders. Urinary measurements of sodium, potassium 17-ketosteroids, hydroxy-steroids and lithium in several of the patients did not help to differentiate them by their reaction to lithium. It is concluded that the notion of lithium as an effective prophylactic agent against recurrent depressions, based on decreased frequency or increased interval between episodes, is not supported by this study.

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Section: Resultsmentioning

confidence: 99%

A Longitudinal Investigation of Lithium as a Prophylactic Agent for Recurrent Depressions

1970

Canadian Psychiatric Association Journal

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“…Fünf kontrollierte Studien konnten zeigen, dass Lithium einer Medikation mit Placebo überlegen ist. Die Ansprechraten dieser 5 Studien zusammengefasst ergaben, dass es bei 87 von 124 Patienten (70%) zu einer Besserung der manischen Symptomatik kam [6,19,29,37,39]. In der vorliegenden Studie erhielten 11 Patienten (12%) zu Beginn der Behandlung keinen Stimmungsstabilisierer.…”

Section: Lithiumunclassified

Medikamentöse Behandlung akuter Manien

et al. 2004

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The aim of the present retrospective chart analysis was to compare published treatment algorithms with the treatment patterns of 90 consecutive inpatients suffering from acute mania or hypomania at the Department of General Psychiatry, University of Vienna, from 1997 to 1999. Treatment strategies during the first 14 days and on discharge as well as sociodemographic and illness related data were evaluated. The results of our study reflect that international guidelines were not included in daily practice from 1997 to 1999 with regard to the usage pattern of atypical antipsychotics versus typical neuroleptics. Also, recommendations have not been taken into account about monotherapy with a mood stabilizer as first-line treatment for acute mania (polypharmacia was the predominant treatment scheme) and the advice to taper off benzodiazepines (at discharge).

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“…With few exceptions numerous investigators have confirmed Cade's original observations concerning lithium's effectiveness in combating mania. Under double-blind conditions, 4 of these studies (2,3,4,5) have shown lithium to be superior to placebo in reducing manic symptoms. Apart from these 4 double-blind studies, an estimated 6,000 patients in many countries have been given lithium by a variety of research teams numbering near 400.…”

Section: Therapeutic Value In Maniamentioning

confidence: 99%

Clinical Controversies and Theoretical Mode of Action of Lithium Carbonate

Fieve¹

1970

Int Pharmacopsychiatry

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Cade’s (1) discovery in 1949 of lithium’s therapeutic success in mania has precipitated two decades of continuing investigations, clinical trials and controversial findings. With few exceptions numerous investigators have confirmed Cade's original observations concerning lithium’s effectiveness in combating mania. Under double-blind conditions, 4 of these studies (2, 3, 4, 5) have shown lithium to be superior to placebo in reducing manic symptoms. Apart from these 4 double-blind studies, an estimated 6,000 patients in many countries have been given lithium by a variety of research teams numbering near 400. A review of these open studies to date reveals that on the average 80 % of all manic patients treated have responded quickly and satisfactorily to lithium carbonate. Of note is the fact that this success in mania was independent of age, sex or duration of the manic disorder.

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Treatment of Manic Illness with Lithium Carbonate

Cited by 201 publications

References 15 publications

A Longitudinal Investigation of Lithium as a Prophylactic Agent for Recurrent Depressions

A Longitudinal Investigation of Lithium as a Prophylactic Agent for Recurrent Depressions

Medikamentöse Behandlung akuter Manien

Clinical Controversies and Theoretical Mode of Action of Lithium Carbonate

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