Treatment of malignant ovarian germ cell tumors with preservation of fertility: A report of 28 cases

Wu, Ping; Rl, Huang; Lang, Jing He; Huang, Houfeng; Lian, L; My, Tang

doi:10.1016/0020-7292(91)90521-6

Cited by 12 publications

(20 citation statements)

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“…In particular, patients with seminomas are more likely to have received radiotherapy. Some investigators assumed that married patients desired children and unmarried patients did not (Wu et al, 1991). In contrast, the data presented here rely almost entirely on fertility rates as reported by patients.…”

Section: Discussionmentioning

confidence: 89%

“…While there are many theoretical reasons why chemotherapy may induce infertility, it would appear that the risks of this occurring are small. Pektasides 40 17 0% POMB/ACE 6 5 1 (17%) Gershenson (Gershenson, 1988) 40 40 N/A b Various 16 11 5 (31%) Huang (Huang, 1990) 28 26 8% N/A 10 7 3 (30%) Wu (Wu et al, 1991) 28 22 7% Various 10 7 3 (30%) Long (Long et al, 1993) 15 15 N/A N/A N/A 4 N/A Mitchell 69 26 0% Various N/A 11 N/A Brewer (Brewer et al, 1999) 26 16 100% BEP a 5 3 2 (40%) Perrin (Perrin et al, 1999) 45 29 51% Various 9 7 2 (22%) Low (Low et al, 2000) 91 39 42% Various 20 19 1 (5%) Kanazawa (Kanazawa et al, 2000) 31 18 23% Various 9 8 1 (11%) Zanetta (Zanetta et al, 2001) 169 73 41% Various 20 16 4 (20%) Tangir (Tangir et al, 2003) 106 Fertility after chemotherapy for germ cell tumours J Gaffan et al…”

Section: Discussionmentioning

confidence: 99%

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Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

et al. 2003

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The risk of chemotherapy-induced infertility in male and female germ cell tumour (GCT) survivors is unclear, but may correlate with cisplatin dose. Here, we examine a large series of GCT patients for the effect of chemotherapy on those attempting to have children. Our GCT database was screened for nonseminomatous GCT patients who had (1) received POMB/ACE chemotherapy (cisplatin, vincristine, methotrexate, bleomycin alternating with actinomycin D, cyclophosphamide and etoposide) and (2) stage I male GCT patients who were untreated between 1977 and 1996. Fertility was assessed by questionnaire and medical records. A total of 64 of 153 treated and 35 of 115 untreated men attempted to have children. In all, 28% (18 out of 64) receiving POMB/ACE were unsuccessful. Radiotherapy (six), atrophic remaining testis (one) or prior infertility (three) were implicated in 10 cases, so chemotherapy-induced infertility may have occurred in only 11% (eight out of 64). Strikingly, 26% (nine out of 35) of untreated stage I patients also failed to have children (three had radiotherapy, three prior infertility). Moreover, in treated men, no association was seen between cisplatin dose and infertility. In contrast, radiotherapy significantly increased male infertility (P ¼ 0.001). Of 28 treated women who attempted to have children, 25% (seven out of 28) were unsuccessful. One previously had infertility and one subsequently had successful IVF so chemotherapy-induced infertility potentially occurred in only 18% (five out of 28) and was not related to cisplatin dose. In conclusion, the risk of chemotherapy-induced infertility is low in both male and female GCT patients and does not clearly correlate with the cumulative cisplatin dose.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

et al. 2003

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“…Patients who receive conservative surgery with the preservation of one ovary retain acceptable fertility rates despite adjuvant treatment with chemotherapy. There has been no report of higher adverse obstetric outcome or long-term unfavorable sequelae in the offspring [107][108][109][110].…”

Section: Diagnosis Staging and Surgical Managementmentioning

confidence: 99%

Cancer of the ovary, fallopian tube, and peritoneum

Berek

Crum

Friedlander

2015

Intl J Gynecology & Obste

123

119

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“…Preservation of fertility remains problematic after chemotherapy for the treatment of malignant ovarian tumors. However, it has been reported that gonadal function is not permanently impaired and that fertility can be preserved in the majority of patients receiving CDDP-based adjuvant chemotherapy [9,10,13,14].…”

Section: Discussionmentioning

confidence: 99%

Management of Malignant Ovarian Tumors in Young Women

Koshiyama

Yoshida²,

Takemura³

et al. 1998

Gynecol Obstet Invest

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To evaluate the management of malignant ovarian tumors in young women who wish to maintain fertility, we retrospectively reviewed ovarian malignancies in 21 young women who were both nulliparous and under 40 years of age. With stage 1a disease, all 9 patients were treated with conservative surgical therapies, and all of them are still alive, irrespective of histological type. With stage 1c disease, 5 (83%) of 6 patients were treated with conservative surgical therapies. Among them, 2 patients with epithelial tumors, who were treated with conservative surgical therapies and potent cis-diamminedichloroplatinum (CDDP)-based combined chemotherapies, are still alive. Furthermore, one of them had a successful pregnancy. On the other hand, 3 out of 4 patients with nonepithelial tumors were treated with conservative surgical therapies. However, 2 (67%) out of 3 died; both of them were treated with non-CDDP-based chemotherapy. In 6 patients with disease beyond stage 2, 4 (67%) were treated with radical surgical therapies, but 2 (33%) were treated with conservative surgery and CDDP-based combined chemotherapy, one of which was followed by a successful pregnancy in spite of nonepithelial tumor. As above, we could obtain some successful pregnancies in cases beyond stage 1c after conservative surgery by adding definite CDDP-based combined chemotherapy. However, we must carefully select the patients with nonepithelial tumors for conservative therapy by adding definite CDDP-based combined chemotherapy and inform them of the risks of therapy.

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Treatment of malignant ovarian germ cell tumors with preservation of fertility: A report of 28 cases

Cited by 12 publications

References 0 publications

Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

Cancer of the ovary, fallopian tube, and peritoneum

Management of Malignant Ovarian Tumors in Young Women

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