Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation.

Appelbaum, FR; Sullivan, Keith M.; Cd, Buckner; Clift, R A; Deeg, H. Joachim; Fefer, A; Hill, Roger; Mortimer, Joanne; Pe, Neiman; Sanders, Jean E.

doi:10.1200/jco.1987.5.9.1340

Cited by 224 publications

(78 citation statements)

References 31 publications

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“…The dose of etoposide was reduced by 25% in two patients (Philip et al, 1987). Moreover, long term disease free survival is around 20% in non selected groups of patient, (Takvorian et al, 1987;Appelbaum et al, 1987;Phillips et al, 1990) results not much better than those achieved with conventional salvage therapy alone. This indicates that in relapsed NHL, intensive chemotherapy with ABMT only has a place in patients who have sensitive disease and low tumour burden after salvage therapy (Philip et al, 1987;Takvorian et al, 1987).…”

Section: Patient Selectionmentioning

confidence: 95%

“…When comparing these regimens in terms of response it is clearly crucial to be mindful of the difference in case selection (Press et al, 1991). Patients with primary resistant lymphomas and resistant relapse do particularly badly (Cabanillas et al, 1982;Cabanillas et al, 1987;Philip et al, 1987;Takvorian et al, 1987;Appelbaum et al, 1987;Phillips et al, 1990). Several othe prognostic features for relapsed lymphoma have been reported.…”

Section: Patient Selectionmentioning

confidence: 99%

See 1 more Smart Citation

EPIC: an effective low toxicity regimen for relapsing lymphoma

Hickish

Roldán²,

Cunningham³

et al. 1993

Br J Cancer

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Section: Patient Selectionmentioning

confidence: 95%

Section: Patient Selectionmentioning

confidence: 99%

EPIC: an effective low toxicity regimen for relapsing lymphoma

Hickish

Roldán²,

Cunningham³

et al. 1993

Br J Cancer

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“…The median time to reach more than 0.5 × 10 9 /l ANC was 16 (range, [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] …”

Section: Engraftmentmentioning

confidence: 99%

“…Non-randomized studies demonstrated a reduction of relapse by approximately half compared to autologous transplantation, but this advantage was upset by the high treatment-related mortality. [12][13][14][15] Nevertheless, some patients with poor prognosis NHL attain long-term clinical remissions. [16][17][18][19][20] As other hematologic malignances NHLs are characterized by non-random genetic alterations.…”

Section: Introductionmentioning

confidence: 99%

True

2001

Leukemia

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From 1987 to 1999 35 patients with poor prognosis non-Hodgkin's lymphoma (NHL) underwent allogeneic stem cell transplantation (SCT) at the University Hospitals of Vienna and Graz. Initial biopsy specimens were reclassified according to the Revised European-American Classification of Lymphoid Neoplasms (REAL). All patients surviving 28 days engrafted. Twenty-eight of them (93%) attained clinical remission. At the last follow-up 14 patients were alive and disease-free at a median of 5.0 (range, 2.3-12.9) years after allogeneic SCT. The actuarial overall survival is 35%. Five patients relapsed 1.8 to 27.6 months after transplant, the probability of relapse is 23%. Of the 21 deaths following SCT, seven were due to relapse/refractory disease and 14 due to transplant-related causes. The probability of treatment-related mortality is 48%. After SCT, minimal residual disease (MRD) was monitored by polymerase chain reaction (PCR) in seven patients with a BCL-2/IgH translocation and in 13 with a clonal immunoglobulin heavy chain (IgH) rearrangement. All 20 patients attained clinical remission rapidly and converted to PCR negativity. In the follow-up nine of these patients are in long-term clinical and molecular remission, six PCR-negative patients died of transplant-related causes and five patients relapsed. In summary, allogeneic stem cell transplantation has a curative potential for patients with refractory and recurrent non-Hodgkin's lymphoma. In our series long-term disease-free survival was associated with molecular disease eradication after SCT. Treatmentrelated mortality rate was high, thus earlier referral of selected patients to allogeneic SCT should be considered. Leukemia (2001) 15, 635-641.

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“…Several studies in patients with NHL have reported lower relapse rates after allogeneic BMT than after autologous transplant. [5][6][7][8][9] Lastly, in recent years, the risk of long-term complications such as myelodysplasia and secondary leukemias following autologous BMT for lymphoma has been recognized with increasing frequency. 10,11 If the morbidity and mortality associated with allogeneic transplantation could be reduced, then it might prove a superior alternative to autologous transplant procedures in certain patients with recurrent lymphoma.…”

mentioning

confidence: 99%

CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin’s lymphoma

Soiffer

Freedman

Neuberg

et al. 1998

Bone Marrow Transplant

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Summary:For patients with non-Hodgkin's lymphoma (NHL) undergoing blood or bone marrow transplantation (BMT), the use of autologous grafts has often been preferred to that of allogeneic stem cells because of a significantly lower incidence of non-relapse mortality. If complications associated with allo-BMT could be minimized without compromising efficacy, then it might become a preferred strategy for certain subsets of patients. In this report, we describe the toxicity and long-term efficacy of T cell-depleted allogeneic BMT using anti-CD6 monoclonal antibody and complement alone to reduce the risk of GVHD and its sequelae. Twenty-two patients, aged 18-60 years, with high (n = 10), intermediate (n = 9), or low (n = 3) grade NHL underwent HLA-identical allogeneic BMT from siblings. Patients had either relapsed after at least one remission or never achieved a full remission with chemotherapy. Twenty patients had a history of marrow involvement. Bone marrow was depleted of CD6 + T cells with T12 monoclonal antibody and complement as the sole form of GVHD prophylaxis. Stable hematopoietic engraftment occurred in all 22 patients. Four patients developed grade 2 and 1 patient grade 3 GVHD (23% grades 2-4 GVHD). Chronic GVHD has occurred in three patients. Treatment-related mortality was very low. Only one patient died while in remission. Thirteen patients are alive and free of disease with a median follow-up of 30 months. Estimated event-free and overall survivals are 54 and 59%, respectively. CD6 allogeneic marrow transplantation is associated with a low risk of transplant-related complications and may offer advantages for certain patients with recurrent NHL felt to be at high risk for relapse after autologous transplantation.

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Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation.

Cited by 224 publications

References 31 publications

EPIC: an effective low toxicity regimen for relapsing lymphoma

EPIC: an effective low toxicity regimen for relapsing lymphoma

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CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin’s lymphoma

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