Treatment of malcirculation in lower extremities by LDL adsorption.

Improvements in Artery Occlusion by Low‐Density Lipoprotein Apheresis in a Patient with Peripheral Arterial Disease

“…For the treatment of PAD, antiplatelet and prostaglandin preparations are usually administered and surgery has been performed, but in severe cases of PAD surgical reconstruction of the artery or bypass‐graft surgery is very difficult. Since Agishi et al (2) reported the effectiveness of low‐density lipoprotein apheresis (LDL‐A) in treating PAD patients whose conditions were complicated by hypercholesterolemia, the clinical effect of LDL‐A on PAD has been supported regardless of serum cholesterol levels (3,4). For the angiographic change effected by LDL‐A, several reports have described the conditions of the lower limbs in patients before and after they underwent LDL‐A, but there is no paper that reports on the improvement in the total occlusion of the peripheral artery.…”