Treatment of lymphomas via regulating the Signal transduction pathways by natural therapeutic approaches: A review

Batool, Ammara; Hazafa, Abu; Ahmad, Safeer; Khan, Hina; Abideen, Hafiz M.Z.; Zafar, Ayesha; Bilal, Muhammad; Iqbal, Hafiz M.N.

doi:10.1016/j.leukres.2021.106554

Cited by 5 publications

(5 citation statements)

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“…CUR is a diarylheptanoid-based natural compound, and its chemical structure reveals the presence of carbonyl and phenolic groups. CUR is mainly composed of turmeric compounds (2–8%) and is an excellent source of yellow turmeric [ 117 ]. It is also used in TNBC as it interferes with the EMT process and inhibits BC cell migration [ 118 ].…”

Section: Synergistic Approach Of Natural Products Against Bcmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. This review focused on the emerging roles of novel natural products and derived bioactive compounds as therapeutic agents against BC. The present review also discussed the mechanism of action through signaling pathways and the synergistic approach of natural compounds to improve their efficacy. We discussed the recent in vivo and in vitro studies for exploring the overexpression of oncogenes in the case of BC and the current status of newly discovered natural products in clinical investigations.

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Section: Synergistic Approach Of Natural Products Against Bcmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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“…PD-1 inhibitors activate the immune system to attack tumors. NF-κB induces PD-L1 gene transcription by binding to its promoter, leading to up-regulation that promotes oncogenesis, inflammatory cytokines, and other cellular responses [43,44]. Hence inhibiting NF-κB signalling can possibly reduce PD-L1 expression and tumor growth.…”

Section: Diagnosis and Current Treatment Of Hodgkin Lymphomamentioning

confidence: 99%

“…Several natural plants were shown to possess activities against lymphomas including HL in a review on natural compounds such curcumin, Japanese apricot, resveratrol, bromelain, Annonaceous acetogenins etc. [44]. Some early tumors might express signs and symptoms which can be observed, however it's not usually the situation.…”

Section: Diagnosis and Current Treatment Of Hodgkin Lymphomamentioning

confidence: 99%

Hodgkin Lymphoma in Nigeria: Prevalence, Mechanisms of Tumorigenesis and Diagnosis

Dokunmu¹

2021

AABSc

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Hodgkin lymphoma (HL) is an uncommon neoplasm where tumor stems from a certain kind of leukocytes known as B-cell. This lymphoid malignancy involves outlying lymph gland which may extend to tissues. Research estimates 40% of patients are diagnosed from constitutive signs while early detection is a challenge. The Hodgkin Reed-Stenberg cells is established as the hallmark of Hodgkin lymphoma but multiple underlying mechanisms are involved. Hodgkin lymphoma spreads across different regions with limitations of effective control, hence there is a need to fully understand its tumorigenesis and diagnosis. We reviewed the multiphase deregulated signalling pathways and several interactions amongst cells, these characteristics can proffer new breakthrough to target therapeutics either through direct inhibition of affected signalling pathways or Hodgkin Reed-Stenberg cells associated with diverse cellular infiltrates within the lymph cell. HL incidence in Nigeria is similar to the incidence in other regions but there is a higher death rate in Nigeria. Nigeria bears the second highest burden of HIV globally which contributes to incidence of HL. Also, Epstein-Barr virus increases the risk of the disease, which is also prevalent in Nigeria. Lymphomas are associated with higher cancer-related deaths especially in HIV-infected persons with 2.5times lower 2-year survival chance compared to HIV-uninfected persons and late stage of lymphoma was also a contributing factor to the survival outcomes. Hence, to reduce the burden of the disease, an understanding of the aetiology, epidemiology, and biochemical mechanisms of the lymphoma is needed which are herein reviewed.

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“…Lymphoma, a heterogeneous group of malignancies, comprises approximately 4.2% of new cases and 3.3% of deaths worldwide in 2019 [ 8 ]. Excess body weight has also been found to be associated with an increased risk of lymphomas, e.g., diffuse large B-cell lymphoma (DLBCL) [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

Wang

Guo

Shi

et al. 2023

J Exp Clin Cancer Res

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Background Excess body weight has been found to associate with an increased risk of lymphomas and some metabolic pathways are currently recognized in lymphomagenesis. Bioactive lipid metabolites such as sphingosine-1-phosphate (S1P) have been proposed to play an important role linking obesity and lymphomas. However, the underlying mechanism(s) of S1P signaling in obesity-lymphomagenesis have not been well addressed. Methods The gene expression of sphingosine kinase (SPHK), lymphoma prognosis, and S1P production were analyzed using Gene Expression Omnibus (GEO) and human lymphoma tissue array. Obesity-lymphoma mouse models and lymphoma cell lines were used to investigate the S1P/SPHK-YAP axis contributing to obesity-lymphomagenesis. By using the mouse models and a monocyte cell line, S1P-mediated polarization of macrophages in the tumor microenvironment were investigated. Results In human study, up-regulated S1P/SPHK1 was found in human lymphomas, while obesity negatively impacted progression-free survival and overall survival in lymphoma patients. In animal study, obesity-lymphoma mice showed an aggressive tumor growth pattern. Both in vivo and in vitro data suggested the existence of S1P-YAP axis in lymphoma cells, while the S1P-ALOX15 signaling mediated macrophage polarization towards TAMs exacerbated the lymphomagenesis. In addition, treatment with resveratrol in obesity-lymphoma mice showed profound effects of anti-lymphomagenesis, via down-regulating S1P-YAP axis and modulating polarization of macrophages. Conclusion S1P/S1PR initiated the feedback loops, whereby S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth, while S1P-ALOX15 signaling mediated TAMs contributing to immunosuppressive microenvironment in obesity-lymphoma. S1P-targeted therapy could be potentially effective and immune-enhancive against obesity-lymphomagenesis. Graphical Abstract

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Treatment of lymphomas via regulating the Signal transduction pathways by natural therapeutic approaches: A review

Cited by 5 publications

References 100 publications

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

Hodgkin Lymphoma in Nigeria: Prevalence, Mechanisms of Tumorigenesis and Diagnosis

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

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