Treatment of Lung Cancer with Bronchial Artery Infusion of Cisplatin and Intravenous Sodium Thiosulfate Rescue

Uchiyama, Noriaki; Kobayashi, Hiroaki; Nakajo, Masayuki; Shinohara, Shinji

doi:10.3109/02841868809090319

Cited by 14 publications

(12 citation statements)

References 11 publications

(8 reference statements)

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“…12,13 Infusion of anticancer drugs by a selective catheterization of the bronchial or pulmonary arteries feeding the tumor is less invasive than ILP, and tumor regression has been reported, without severe complications but survival time was not prolonged. 6,14,15 As a rapid drug washout at the end of the infusion may decrease local antitumor efficacy, 7 PACE with ethiodized oil has been recently proposed for the treatment of unresectable lung metastases. 8,16 This transcatheter technique consists of the local delivery of high concentrations of chemotherapeutic agents emulsified in ethiodized oil, associated with vessel occlusion with an embolic material.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary artery chemoembolization in a sheep model: Evaluation of performance and safety of irinotecan eluting beads (DEB‐IRI)

Baylatry¹,

Pelage²,

Wassef³

et al. 2011

J Biomed Mater Res

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The purpose of this study was to evaluate and compare plasma pharmacokinetics, lung tissue concentration, and the potential toxicity of drug eluting beads loaded with irinotecan (DEB-IRI) in a sheep pulmonary artery chemoembolization (PACE) model. Sheep (n = 24) were embolized with DEB-IRI loaded with different doses (0, 20, 50, or 100 mg). Direct pulmonary artery (PA) injections of irinotecan were also performed at two doses (50 or 100 mg; n = 4 sheep). Irinotecan was quantified in plasma and lung tissue (liquid chromatography-fluorescence detection); pathological examination of lungs was performed 4 days or 4 weeks after PACE. Irinotecan was detected in the systemic circulation within a few minutes after PACE, for several hours in DEB-IRI 20 and DEB-IRI 50 groups, and for 24 hours for DEB-IRI 100. Both Cmax and AUC values increased significantly with dose (p = 0.0078 and p = 0.0008, respectively) after PACE. Cmax and AUC values were significantly reduced (by 80%, p = 0.0036, and by 50%, p = 0.0393, respectively) after PACE than after direct PA injection. Irinotecan was not detected in tissue 4 days after PACE. No sign of lung toxicity was observed, except a limited hemorrhagic angionecrosis seen 4 days after PACE with DEB-IRI 100. Inflammatory response on beads was moderate in all DEB-IRI groups. Compared to other routes of administration, DEB loaded with irinotecan at doses up to 100 mg was well tolerated. DEB loaded with 100 mg irinotecan seem a promising candidate for future PACE trials in patients.

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Section: Introductionmentioning

confidence: 99%

Pulmonary artery chemoembolization in a sheep model: Evaluation of performance and safety of irinotecan eluting beads (DEB‐IRI)

Baylatry¹,

Pelage²,

Wassef³

et al. 2011

J Biomed Mater Res

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“…To treat patients with localized tumors, TRC using i.a. infusion of DDP and systemic administration of STS is often prescribed (Uchiyama et al, 1988;Abe et al, 1988). Furthermore, i.a.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of two‐route chemotherapy using cis‐diamminedichloroplatinum(II) and its antidote, sodium thiosulfate, combined with the angiotensin‐II‐induced hypertension method in a rat uterine tumor

Kobayashi¹,

Hasuda²,

Taniguchi³

et al. 1991

Intl Journal of Cancer

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To enhance the therapeutic effect of conventional TRC using intra-arterial (i.a.) DDP plus simultaneous i.v. STS, we combined the AT-II-induced hypertension method with TRC and evaluated its efficacy for a rat uterine tumor, using the simulation of intra-arterial chemotherapy for human uterine tumors. During interruption of arterial blood flow by vascular manipulations, DDP plus AT-II were injected for 10 min through the abdominal aorta in the direction of the uterus. Then STS was administered i.v. for a further 5 min and all the arterial restrictions were released. This modified TRC using AT-II showed a much higher anti-tumor effect than that seen in conventional TRC without AT-II and was free from DDP-induced renal damage. On the other hand, severe nephrotoxicity was unavoidable in the rats given the delayed i.v. administration of STS to i.a. DDP alone. The feasibility of post-administration of STS without obvious nephrotoxicity in modified TRC was explained by transient inhibition of DDP delivery to the kidney during the AT-II-induced hypertension. The loss of body weight and the decrease in the number of leukocytes after this therapy were tolerable. Modified TRC showed a higher anti-tumor effect and a lower nephrotoxicity compared with other treatments, as follows: DDP i.a. with or without AT-II; i.v. infusion of DDP alone. Such a superior anti-tumor effect of modified TRC consists of the following 2 factors: (i) the post-administration of STS leading to the delayed neutralization of DDP at the tumor site; (ii) the selective enhancement of DDP delivery to the tumor tissue during AT-II-induced hypertension.

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“…CDDP is an effective anticancer agent used in the treatment of various malignancies. 14 Ono et al 15 reported that TACE using a suspension of CDDP powder in LPD was more effective against unresectable HCC than that using an emulsion of ADM and LPD. Other investigators have also frequently reported favorable results obtained with TACE using a suspension of CDDP powder in LPD in HCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…9,12,13 Cisplatin (CDDP), a platinum compound, is an effective anticancer agent used in the treatment of various malignancies. 14 Researchers have recently reported that TACE using a suspension of CDDP in LPD may be more effective against unresectable HCC than that using ADM-LPD emulsion. 15,16 Moreover, a fine-powder formulation of CDDP (DDPH, IA-call; Nipponkayaku, Tokyo, Japan) has also been available since 2004 as a therapeutic agent for intra-arterial infusion in Japan.…”

Section: Introductionmentioning

confidence: 99%

Transcatheter Arterial Chemo-Embolization with a Fine-Powder Formulation of Cisplatin for Unresectable Hepatocellular Carcinoma

Kasai¹,

Suzuki²

2012

Hepatocellular Carcinoma - Clinical Research

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Treatment of Lung Cancer with Bronchial Artery Infusion of Cisplatin and Intravenous Sodium Thiosulfate Rescue

Cited by 14 publications

References 11 publications

Pulmonary artery chemoembolization in a sheep model: Evaluation of performance and safety of irinotecan eluting beads (DEB‐IRI)

Pulmonary artery chemoembolization in a sheep model: Evaluation of performance and safety of irinotecan eluting beads (DEB‐IRI)

Therapeutic efficacy of two‐route chemotherapy using cis‐diamminedichloroplatinum(II) and its antidote, sodium thiosulfate, combined with the angiotensin‐II‐induced hypertension method in a rat uterine tumor

Transcatheter Arterial Chemo-Embolization with a Fine-Powder Formulation of Cisplatin for Unresectable Hepatocellular Carcinoma

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