Treatment of lower torso stages I and Ii Hodgkin's disease with radiation with or without adjuvant mechlorethamine, vincristine, procarbazine, and prednisone

Abstract

From 1956 to 1987, 60 patients with either lymphangiogram-staged or laparotomystaged 1-11 lower torso presentations of Hodgkin's disease were treated with radiation with or without Mustargen (mechlorethamine), vincristine, procarbazine, and prednisone (MOPP). In 22 with inguinal/femoral or pelvic disease and 24 with abdominal disease, treatment consisted of radiation only. Fourteen other patients with abdominal disease received MOPP chemotherapy before radiotherapy. In 11, the chemotherapy was limited to two cycles. At 10 years, the determinate survival and freedom from progression rates for all patients were 82% and 72%, respectively. For patients with inguinal/femoral or pelvic disease who were treated with radiation only, the corresponding rates were 90% and 86%. For patients with abdominal disease who received radiation only, the determinate survival and the freedom from progression rates were only 66% and 5070, respectively. However, corresponding results for 14 patients with abdominal disease who were treated with MOPP and radiation were 100% and 92% (P = 0.033 and P = 0.009, respectively). Cancer 66:69-74,1990, URING THE LAST DECADE, investigators have re-

Infradiaphragmatic Hodgkin's disease: the Swedish National Care Programme experience

“…In this study this was not done. With regard to the low recurrence rate in peripheral stage IA in the present study, it is not considered to be necessary, which is in accordance with other reports (13,14).…”

Hodgkin's Disease

“…Para-aortic or spleen involvement requires Combination therapy (50,52,53,55). Given adequate treatment, the results are similar to those achieved in supradiaphragmatic presentation (56).…”

“…No large patient studies have been published, hence it is difficult to know which treatment is the most appropriate. Inverted-Y-irradiation provides good results for disease limited to the femoral/inguinal region (stage IA) (50)(51)(52)(53)(54)(55). The literature provides too little information to draw definitive conclusions regarding whether or not the spleen should be irradiated in this situation.…”