Background: Peripheral arterial disease (PAD) is a common complication in patients with diabetes mellitus, often leading to significant morbidity. Traditional methods for diagnosing PAD, like the Ankle Brachial Index (ABI), may not be sufficient alone, prompting the need for additional predictive markers. Objective: To evaluate the association of inter-arm blood pressure differences (IABPD) alongside ABI in identifying PAD among patients with diabetes mellitus. Methods: This study involved 100 diabetic patients who underwent simultaneous ABI and blood pressure measurement on both arms. The study employed a cross-sectional design to assess the predictive value of IABPD in conjunction with ABI for PAD. Results: Preliminary analysis suggests a significant correlation between IABPD and decreased ABI values, indicating potential utility in PAD screening. Conclusion: IABPD may serve as a valuable adjunctive measure to ABI in diagnosing PAD in diabetic populations, potentially leading to earlier detection and better clinical outcomes.