Treatment of Localized Pulmonary Phycomycosis

Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant

“…Last, the degree of clinical suspicion for infection and the aggressiveness of therapy may influence outcome. Early diagnosis and aggressive management with surgical resection and antifungal administration can significantly improve patient response 17,20,21.…”

Zygomycetes in Human Disease

“…This is due to the availability of good surgical and medical treatments. Localized disease is more likely to be curable by surgery, providing a large survival advantage for this group of patients (117,455). This requires early identification of disease before dissemination occurs.…”

“…Surgical resection for patients with isolated pulmonary disease greatly improved survival compared to that of patients who received antifungal therapy alone (455). Response to surgery is best in cases of localized disease without dissemination (117,455). Although there are several case reports of a single treatment modality producing cure, these are the exception and not the rule.…”

Endoscopic Visualization of Aspergilloma

“…This lack of morphologic features and the isolation of A.fumigatus in the second case would favor another explana tion, since A. fumigatus generally does not develop a yellow color on culture in the laboratory [5]. Another reason for the orange-yellow color of the fungus ball may be due to the collection of serum and hemo globin pigment on the surface of the aspergilloma, from the granulation tissue lining the cavity wall [1], If this explanation is correct then the fungus balls produced by other fungi, such as coccidioidomycosis [7] and phycomycosis [8], should have been orangeyellow rather than brown. Could this difference be tween the color of the aspergilloma and other fungus balls be related to the metabolism of blood pigment by the fungi involved?…”