Treatment of Lichenified Atopic Eczema with Tacrolimus Ointment

Granlund, Håkan; Remitz, Anita; Kyllönen, H; Lauerma, Antti; Reitamo, Sakari

doi:10.1080/00015550152573083

Cited by 11 publications

(1 citation statement)

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“…Other observations in non-typical participants Patients AS1, AS4, AM2 and AM3 continuously applied topical tacrolimus (Protopic ointment). Although this drug is known to reduce the number of Staphylococcus species on the skin (Pournaras et al, 2001;Remitz et al, 2001), the number of Staphylococcus species in the skin of these patients appeared to be the same as that observed in other patients in the analysis of both the molecular T-RF peaks and cultured colonies. This ointment thus appears to be less effective in reducing the number of Staphylococcus species in AD patients in vivo.…”

Section: High Detection Rate Of Streptococcus Species and Phylotypesmentioning

confidence: 52%

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis

Dekio

Sakamoto

Hayashi

et al. 2007

Journal of Medical Microbiology

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A previous study using bacterial 16S rRNA gene-based clone libraries revealed that the microbiota in healthy human skin included uncultured micro-organisms, although the micro-organisms in skin exposed to disease conditions remain to be examined. To compare the profiles of skin microbiota in 13 patients with atopic dermatitis (AD) and 10 healthy controls, terminal RFLP analysis of bacterial 16S rRNA genes was applied to 23 swab-scrubbed samples from facial skin. This culture-independent analysis successfully revealed the complex bacterial members of the microbiota as peak patterns following capillary electrophoresis of terminal restriction fragments (T-RFs). Each T-RF peak reflected a micro-organism, and the micro-organism to which each peak was assigned could be identified by computer simulation of T-RF length using the nucleotide sequence data of bacterial species residing in the skin. Among 18 species detected in the study, Stenotrophomonas maltophilia was detected significantly more commonly in AD patients (5/13 for AD patients vs 0/10 for controls), whilst Dietzia maris was detected significantly more commonly in normal controls (8/10 for controls vs 2/13 for AD patients). Moreover, Streptococcus species, which are considered to be uncommon in uninfected skin, were detected in seven patients and eight normal controls. Although further studies should be undertaken to investigate the roles of these micro-organisms in AD, the microbiota were presumed to include hitherto uninvestigated bacterial species in the major population of patients with AD and of healthy controls.

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Section: High Detection Rate Of Streptococcus Species and Phylotypesmentioning

confidence: 52%

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis

Dekio

Sakamoto

Hayashi

et al. 2007

Journal of Medical Microbiology

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Topical tacrolimus for atopic dermatitis

Cury‐Martins

Martins²,

Aoki

et al. 2015

Cochrane Database of Systematic Reviews

115

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BackgroundAtopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that a ects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse e ects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs). ObjectivesTo assess the e icacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments. Search methodsWe searched the following databases up to 3

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Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

Chu,

Rayner

et al. 2023

Journal of Allergy and Clinical Immunology

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Treatment of Lichenified Atopic Eczema with Tacrolimus Ointment

Cited by 11 publications

References 0 publications

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis

Topical tacrolimus for atopic dermatitis

Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

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