Treatment of Leg Veins for Restless Leg Syndrome: A Retrospective Review

Sundaresan, Swaminathan; Migden, Michael R.; Silapunt, Sirunya

doi:10.7759/cureus.4368

Cited by 4 publications

(5 citation statements)

References 24 publications

(28 reference statements)

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“…Studies have shown that varicose vein surgery can improve RLS symptoms and DS ( 4 , 5 ). A study conducted by Hayes et al assessed the impact of varicose vein operation on RLS symptoms in 35 patients.…”

Section: Discussionmentioning

confidence: 99%

The implications of varicose vein surgery on sleep evaluation scales

Acir,

Okudan Atay,

Atay

et al. 2023

Front. Psychiatry

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BackgroundVaricose veins commonly occur on the legs and cause discomfort, pain, and aesthetic issues. Varicose vein surgery has an significant impact on sleep disorders such as Restless Leg Syndrome (RLS), daytime sleepiness (DS), and sleep quality (SQ). We intended to determine if preoperative and postoperative sleep quality, excessive daytime sleepiness, and RLS severity impacted in those who had varicose vein surgery.Materials and methodsThe research included 160 patients who presented to the Cardiovascular Surgery outpatient clinic with symptoms of leg pain and cramping and were diagnosed with venous insufficiency. The Restless Legs Syndrome Study Group Rating Scale (RLSS), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) tests were performed on patients. The patients’ scores on the scales were compared preoperatively and postoperatively.ResultsThe mean age of the 160 patients was calculated to be 48.7 ± 10.6 years. There were 109 female (68.1%) and 51 male (31.9%). The mean ferritin level of the patients was calculated as 61.4 mL/ng (4.3–421 mL/ng). After varicose vein surgery 63% reported improved sleep quality. Individuals with increased DS had lower postoperative RLSS scores and higher SQ. There was a decrease in postoperative RLSS scores and an increase in postoperative SQ in patients with normal DS (p < 0.001). Postoperative RLSS and DS scores were lower in patients with good SQ (p < 0.001).ConclusionPatients had a lower RLSS score, a lower DS score, and a higher SQ after varicose vein surgery. Surgical treatment is critical to improving the quality of life and sleep comfort of patients with varicose veins and sleep disorders.

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Section: Discussionmentioning

confidence: 99%

The implications of varicose vein surgery on sleep evaluation scales

Acir,

Okudan Atay,

Atay

et al. 2023

Front. Psychiatry

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“…Our results provide new data on rates of RLS symptoms in patients with underlying SVR while corroborating the limited studies which have previously identified a similar association. 4,5,17 Furthermore, the high rate of RLS symptoms in those who found to have SVR suggests an association between the two factors. Therefore, in patients presenting with RLS symptoms, we believe SVR should be actively screened for.…”

Section: Discussionmentioning

confidence: 99%

“…These findings, while limited, are consistent with existing literature on RLS and SVR. 4,5,17 Identifying that SVR associated with RLS symptoms is significant as it provides the possibility of more definitive interventions (i.e., venous ablation of the incompetent superficial venous system by methods including but not limited to radiofrequency, chemical, or surgical ablation) as an alternative to medical management alone. Current estimates of medical management for RLS range from $774 to 2,448 annually 14,16 which makes the typical one-time cost of approximately $2,040 for radiofrequency ablation, a potentially low risk, cost-effective option for treatment.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Restless Leg Syndrome and Superficial Venous Reflux

Dezube

Rauh²,

Dezube³

et al. 2021

Int J Angiol

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Restless leg syndrome (RLS) is a common cause of lower extremity discomfort. We hypothesized that patients with RLS symptoms have higher rates of deep and superficial venous reflux (SVR). Retrospective review of patients ≥18 years of age evaluated in a venous center from December 2018 to February 2019. Differences in rates of RLS symptoms, demographics, comorbidities, and clinical and radiologic presence of venous disease were analyzed. Overall, 207 patients were analyzed; 140 (67.6%) reported RLS symptoms (n = 25 with prior RLS diagnosis). RLS symptoms were more common with superficial or combined superficial and deep venous reflux (DVR) compared with those without reflux (p < 0.001). Patients with RLS symptoms as opposed to those without had similar demographics and comorbidities (all p > 0.05) but increased rates of venous pain, phlebitis, family history of venous disease, lower extremity swelling and SVR, and combined SVR and DVR (all p < 0.05). Our multivariable logistic regression found presence of SVR, and family history of venous reflux was associated with RLS symptomatology (all p < 0.001). Ninety-nine patients with RLS underwent ablation; of them, 93 had duplex-proven reflux resolution of which 81 (87%) reported RLS symptom improvement. This included 13 of 16 (81.3%) with prior RLS diagnosis. SVR is associated with increased rates of RLS symptoms in a vein center population. Therefore, RLS symptoms should trigger a targeted venous evaluation. Our results suggest that venous ablation may lead to resolution of RLS symptoms in patients with SVR, but randomized prospective trials with strict RLS definition criteria are warranted to confirm these outcomes.

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“…Varicose veins has been previously associated with RLS but our study results did not support this notion as the association between RLS and varicose veins based on multiple regression analysis appeared to be non-significant statistically )OR=5.1, 95% CI=0.68-36.92, p=0.11(. 20,[32][33][34] Moreover, 2 of these studies note that an improvement in RLS symptoms often occurs after superficial venous insufficiency is treated surgically. 33,34 According to the RLSSS and based on our linear regression analysis, other predictors of severe RLS include male gender )Coef.=-2.73, 95% CI= Table 6 -Predictors of restless leg syndrome and severe restless leg syndrome among IBD patients according to multiple logistic and linear regression analysis, respectively.…”

Section: Predictors Of Rls and Severe Rls Among Ibdmentioning

confidence: 99%

Inflammatory bowel disease and restless leg syndrome

Mosli

Bukhari

Khoja

et al. 2020

NSJ

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Objectives: Inflammatory bowel disease)IBD(has been associated with restless leg syndrome)RLS(. This study aims to explore the prevalence, clinical predictors, and severity of RLS in IBD patients compared to controls. Methods: We conducted a case-control study between January and December of 2019 comparing IBD patients with controls. Assessment of RLS was Original Article performed using the previously validated diagnostic restless leg syndrome questionnaire)RLSQ(. Logistic regression analyses were applied to investigate associations between patient demographics and clinical features and RLS diagnosis. Results: A total of 218 IBD patients and 211 healthy controls were incorporated after excluding 6 patients with positional discomfort and 4 patients with habitual foot tapping. The mean age was 30.2±11.7 and 64% were females. The prevalence of RLS was 16/218)7.34%(and 17/211)8.06%(among cases and controls, respectively. Based on the RLSQ severity score, 6/16)37.5%(, 4/16)25%(and 1/16)6.3%(of the IBD patients with RLS had mild, moderate and severe RLS; respectively. The odds of IBD were lower among patients with confirmed RLS)OR=0.90, 95% CI=0.44-1.84, p=0.78(. In the logistic regression analysis, only vitamin B12 deficiency)OR=10.20, 95% CI=1.40-74.10, p=0.022(was associated with RLS diagnosis among IBD patients. Conclusion: No difference was found in the prevalence of RLS between IBD patients and non-IBD controls. Vitamin B12 deficiency was associated with RLS diagnosis among patients with IBD.

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Treatment of Leg Veins for Restless Leg Syndrome: A Retrospective Review

Cited by 4 publications

References 24 publications

The implications of varicose vein surgery on sleep evaluation scales

The implications of varicose vein surgery on sleep evaluation scales

Correlation between Restless Leg Syndrome and Superficial Venous Reflux

Inflammatory bowel disease and restless leg syndrome

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