Treatment of Lead Poisoning with Calcium Edta

Abstract

Basophilic red cells Case J. No. -1 Ab$Einal I Anemia stippling of Ethylene diamine tetra-acetic acid (EDTA) is a compound capable of forming stable chelating agents with multivalent metals, such as lead. The resultant lead chelate is rapidly eliminated by the body via the kidneys. Thc lead ion will replace the calcium ion in MATERIAL AND METHODS calcium 'DTA. Hence this compound has Five Intients were treatetl wit11 intravenous i l lbeen administered in cases of lead poisoning filsiolis of c;1Icilll71 EDTA in glucose. T~~ of tllelll for the purpose of eliminating the toxic \cad had cxliibited ;iciite syni1)tonis of lead poisoning. ion from the body. 1952, Rubin, ~i~~~~ For this reason their fellow workmen in the storage Irattery factory where they were employed were & Popovici tried it successfully in cxpericxaminctl, and thus the other three patients were same year the first reports wcrc published toms and definite ohjective signs of lead poisoning. on successful calcium EDTA therapy in All these patients I d been Iiandling lead plates iii beings ( B~~~~~~, Rubill ollc ; hy inlialation of the lead oxide powder covering the Belknap cases). Subsequently favorsurface o f siicli plates. l'lie symptoms are suntion has been confirmed by several writers Hardy, Elkins, Ruotolo, Quinby SL Baker (1954) 3 cases ; Cotter ( 1954) 4 cases ; Eilersen, Astrup, Fallentin & Frost (1955) 4 cases ; Mellemgird & Sarensen (1955) onc case ; Glaniine Cyr Swcnswn (1956) 2 cases).merits On lead-intoxicatcd and in the detected, Tile latter sIlowed mild subjective syl11pacute or chronic lead poisoning in hunlall their work, ;~i t l had probably become intoxicalecl inarizcd in T;il)le T. able effect of calciuln EDTA in this condi-The tilerapy co,,sisted ill (p,iIy illfusiolls of 2.5 fi ED-,-A ill l~c c of a 5 per cent (SidburY, Bynu"' & 1' etz (1953) 7 Cases; rose solution over a two or three hour peritxl for tr11 (lays. n e paticnts sllowing severcr signs (,r Complications T a b 1 e I. Synptotns of 5 paticnts suffering from Icud poisoning.

A perspective Study on Lead Poisoning: Exposure, Effects and Treatment

“…It is a very effective form of treatment as the body comes to its normal state within 2 to 3 days of treatment. It increase urine lead extraction manifolds, thus allowing an effective treatment (Wegelius & Harjanne, 1956).…”