Treatment of Langerhans-cell histiocytosis in children. Experience at the Childrenʼs Hospital of Nancy.

Sessa, S; Santini, Daniele; Lascombes, P.; Prévot, J

doi:10.2106/00004623-199410000-00011

Cited by 86 publications

(40 citation statements)

References 30 publications

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“…Radiotherapy has been advocated for treating radiosensitive tumors, like EG and PNET [26,27]. Our experience provides further evidence in support of this recommendation.…”

Section: Discussionsupporting

confidence: 69%

Primary tumors of the spine: a review of clinical features in 438 patients

et al. 2015

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Primary spinal tumors are rare. Current knowledge on this subject is therefore limited due to the lack of study with large cohort. This study is prompted to share our data on clinical profiles of primary spinal tumors collected from a large series of patients. Clinical manifestations of 438 consecutive patients were summarized retrospectively with statistical analysis. In the spine, benign tumor is more common than malignant. The most prevalent tumor is giant cell tumor. Tumors predominately occur between the age of 18 and 59 and the risk of malignancy increases significantly after 40. Main symptoms include local pain and neurological symptoms with frequent occurrence of neurological deficits and pathological fracture. Pain is caused by tumor expansion, pathological fracture and nerve entrapment. Occurrence of neurological deficits is significantly related to patent's age and the region of involvement. Giant cell tumor is associated with the highest incidence of neurological fracture with significance. Duration of symptom is 6 months on average. The most affected region is the cervical spine, followed by the thoracic and the lumbar spine. Tumors at the sacrum and coccyx are more likely to be malignant. Malignant tumors have significantly higher incidence of involvement at multiple levels than benign tumors. This study contributes by improving our understanding of this rare clinical entity.

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“…Radiotherapy has been advocated for treating radiosensitive tumors, like EG and PNET [26,27]. Our experience provides further evidence in support of this recommendation.…”

Section: Discussionsupporting

confidence: 69%

Primary tumors of the spine: a review of clinical features in 438 patients

et al. 2015

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“…Unifocal lesions without involvement of other organs have the best prognosis; most of them never develop other LCH manifestations [4,8,25,[30][31][32]50]. The clinical course of LCH in patients with multifocal osseous lesions is unpredictable.…”

Section: Discussionmentioning

confidence: 99%

“…Bony manifestations combined with other organ involvement, especially liver, spleen or bone marrow, have the worst prognosis. In those patients, bony lesions tend to relapse more frequently and the disease course is limited by dysfunction of other organs [4,8,25,[30][31][32]50].…”

Section: Discussionmentioning

confidence: 99%

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Strahlentherapie ossärer Manifestationen der Langerhans-Zell-Histiozytose beim Erwachsenen. Review und Vorstellung eines internationalen Registers

Olschewski

Seegenschmiedt

2006

Strahlenther Onkol

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“…Sometimes this is due to diagnostic difficulties, so that the appropriate diagnosis is made in an adult patient. Most scientific reports concern patients aged below 21 [4][5][6].…”

Section: Introductionmentioning

confidence: 99%