Treatment of Kimura disease with photodynamic therapy: A case study

Abbas, Syedda; Jerjes, Waseem; Upile, Tahwinder; Vincent, Anna; Hopper, Colin

doi:10.1016/j.pdpdt.2011.12.002

Cited by 17 publications

(12 citation statements)

References 2 publications

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“…The therapeutic regimen for KD is difficult to assess in the literature, as most data are reported in case reports or short series [8,9,24,25,26]. In patients with a solitary cutaneous lesion and no systemic signs, surgical excision was proposed in first intention with 100% of CR and 60% of relapse.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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Background: Kimura disease (KD) is a rare lymphoproliferative inflammatory disease of unknown etiology. Data regarding therapeutic modalities and pathophysiology are scarce. Objectives: Analyze therapeutic and follow-up data and compare KD with cutaneous IgG4-related disease (IgG4-RD). Methods: Multicentric retrospective study of 25 KD patients with analysis of treatment, follow-up and IgG4 immunostaining. Comparison with published cases of cutaneous IgG4-RD. Results: Patients were mostly male (84%), median-aged 42 years with lymph node, lacrimal/salivary gland and kidney involvements in 45, 24 and 12%, respectively. Surgical excision had 100% complete response and 60% relapse. Oral corticosteroids had 100% response with 50% relapse. Thalidomide, cyclosporine or interferon-α had 100% response, but 100, 20 and 50% relapse, respectively. KD showed clinicopathological similarities with 27 published cases of cutaneous IgG4-RD. Conclusion: Surgery may be used in resectable KD cases, whereas cyclosporine or thalidomide may represent interesting alternatives to oral corticosteroids in other cases. KD shares features with cutaneous IgG4-RD.

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Section: Discussionmentioning

confidence: 99%

“…In unresectable or multiple-lesion KD, thalidomide or cyclosporine regimens could be interesting alternatives to oral corticosteroids. Besides, the reported therapeutic use of leflunomide [8], photodynamic therapy [24], intravenous immunoglobulins [25] or rituximab [29] deserves further evaluation.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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“…Photodynamic therapy has been used in individual case reports for recurrences. 24 Other include omalizumab. 25 Prognosis is good.…”

Section: Discussionmentioning

confidence: 99%

A rare association of Kimura’s disease with chronic pulmonary aspergillosis

et al. 2018

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Kimura’s disease is a rare chronic benign inflammatory condition characterised by nodules of skin and soft tissue and lymphnodes. Eosinophilic infiltration is a prominent finding. It has been reported in association with various conditions like nephrotic syndrome, bronchial asthma, ulcerative colitis and aortitis syndrome. Hereby we present a case in medical literature to the best of our knowledge in Kimura’s disease in association with chronic cavitary pulmonary aspergillosis, which has never been reported. He was treated with antifungals, after which he responded clinically, eosinophilia has subsided and he is under regular follow up. Now This case report suggest possible role of chronic aspergillosis as a cause for Kimura’s disease.

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“…Despite various efforts to establish a definitive treatment for KD, none has yet been identified. The usual methods of treatment include observation, drug administration (14,15), immunosuppressive therapy including tacrolimus (FK-506) (16), radiotherapy (17,18), surgical excision (19) and photodynamic therapy (20). Among them, surgical excision is considered the most effective as it provides not only a treatment for AD, but also a sample for histopathological investigations in order to facilitate an accurate diagnosis (19).…”

Section: Discussionmentioning

confidence: 99%

Kimura's disease of the right cheek: A case report

Luo

Liu³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Kimura's disease (KD), a chronic inflammatory disease of uncertain etiology, manifests as a painless subcutaneous swelling in the head and neck region that involves major salivary glands and regional lymph nodes. To date, the majority of cases of KD have been documented in Asian males aged 20-30 years. However, the number of reported cases of KD involving the oral and maxillofacial area is limited, and since the masses appear similar to cysts or benign tumors, the establishment of an accurate pre-operative diagnosis is challenging. The accurate diagnosis of KD is considered to require surgical excision followed by histopathological examination. In the current case, a 39-year-old man was admitted to hospital in October 2011 with a swelling evident on his right cheek. Surgical excision was performed, and histopathological observation was carried out. The formation of a lymphoid nodule accompanied by the vigorous proliferation of small blood vessels, eosinophilic infiltration and thickened cell walls were observed. No sign of recurrence of the mass has yet been observed, on the basis of the telephone follow-up interviews. These findings provide a novel insight useful in the diagnosis of KD in the oral and maxillofacial area. IntroductionKimura's disease (KD), a chronic inflammatory disease characterized by slowly growing subcutaneous nodules and benign reactive lymphoid proliferation in the face and neck region is predominantly observed in young Asian men (1). It is considered to be a benign disease involving subcutaneous tissues, major salivary glands and lymph nodes in the area of head and neck (2). Although numerous researchers have conducted investigations into the etiology of KD (3-5), reports concerning the underlying etiology of KD in oral and maxillofacial areas are limited (6). Until recently, the underlying cause of KD was unknown (7) In addition, the diagnosis of KD prior to surgery has proven challenging, since a clinical examination alone may not give an accurate diagnosis (8). In the present study, a case of KD affecting the oral and maxillofacial areas was evaluated and the corresponding pathogenesis was reported. Case reportThe patient in the present case was an otherwise healthy 39-year-old man. The patient was admitted to the Shanghai East Hospital Affiliated with Tongji University (Shanghai, China) in October 2011 with an obvious swelling on his right cheek (Fig. 1A). The patient had a 2-year history of non-painful swelling of the right-side cheek without additional symptoms. Three weeks prior to presentation, the patient sought medical attention and self-treated with an anti-bacterial agent administered orally (the name and dose of the drug are unknown). After a 3-week treatment, the mass only minimally responded to over-the-counter medication and no improvement in the patient's condition was exhibited. Therefore, the patient was referred to our hospital for further evaluation and treatment. According to the investigation conducted at the hospital, there was no history of recent febril...

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Treatment of Kimura disease with photodynamic therapy: A case study

Cited by 17 publications

References 2 publications

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

A rare association of Kimura’s disease with chronic pulmonary aspergillosis

Kimura's disease of the right cheek: A case report

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