Treatment of Kimura Disease With Intravenous Immunoglobulin

Hernández-Bautista, Víctor Manuel; Yamazaki‐Nakashimada, Marco Antonio; Vazquez-García, Ruben; Stamatelos-Albarrán, Daniela; Carrasco-Daza, Daniel; Rodríguez-Lozano, Ana Luisa

doi:10.1542/peds.2010-1623

Cited by 22 publications

(18 citation statements)

References 10 publications

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“…The therapeutic regimen for KD is difficult to assess in the literature, as most data are reported in case reports or short series [8,9,24,25,26]. In patients with a solitary cutaneous lesion and no systemic signs, surgical excision was proposed in first intention with 100% of CR and 60% of relapse.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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Background: Kimura disease (KD) is a rare lymphoproliferative inflammatory disease of unknown etiology. Data regarding therapeutic modalities and pathophysiology are scarce. Objectives: Analyze therapeutic and follow-up data and compare KD with cutaneous IgG4-related disease (IgG4-RD). Methods: Multicentric retrospective study of 25 KD patients with analysis of treatment, follow-up and IgG4 immunostaining. Comparison with published cases of cutaneous IgG4-RD. Results: Patients were mostly male (84%), median-aged 42 years with lymph node, lacrimal/salivary gland and kidney involvements in 45, 24 and 12%, respectively. Surgical excision had 100% complete response and 60% relapse. Oral corticosteroids had 100% response with 50% relapse. Thalidomide, cyclosporine or interferon-α had 100% response, but 100, 20 and 50% relapse, respectively. KD showed clinicopathological similarities with 27 published cases of cutaneous IgG4-RD. Conclusion: Surgery may be used in resectable KD cases, whereas cyclosporine or thalidomide may represent interesting alternatives to oral corticosteroids in other cases. KD shares features with cutaneous IgG4-RD.

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Section: Discussionmentioning

confidence: 99%

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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“…A dose of 5 mg/kg/d was effective, but, in most cases, the lesions recurred upon cessation of therapy [17]. Intravenous immunoglobulin (IVIG) was used in one patient as a steroid-sparing agent, and he remained disease free more than 6 years after follow-up [18]. Oral pentoxifylline has been reported to be effective in one patient with Kimura's disease; however, the lesions relapsed after discontinuation of therapy [19].…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease—A Rare Cause of Head and Neck Swelling

Rao¹,

Kumar²

2014

IJOHNS

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Kimura's disease (KD) is a chronic inflammatory disorder with unknown etiology, most commonly manifesting as painless unilateral cervical lymphadenopathy or subcutaneous masses in the head or neck region. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. Kimura's disease is an unusual vascular tumor that typically occurs at 20 to 30 years of age. There has been no documented case of malignant transformation; however, recurrence rates after excision may be as high as 25%. Surgery and medical therapy are useful for treatment. We present a 14 years old male developed a unilateral cervical mass associated with KD. It was a recurrence of disease. As a complete excisional resection of the mass already done 1 year back at some other centre, we decided to give medical treatment for Kimura's disease.

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“…Due to intermittent dependency on corticosteroid, immunoglobulin therapy was tried for the treatment of Kimura's disease as a steroidsparing therapy. 3 Recently, a study showed the efficacy of tacrolimus on Kimura's disease. 10 The 2 previously reported patients with IgA nephropathy were treated with corticosteroids and showed significant decrease in proteinuria.…”

Section: Discussionmentioning

confidence: 99%

“…2 Additional characteristics include marked peripheral eosinophilia and elevated immunoglobulin E (IgE) levels. 3 Kidney involvement occurs in 12-16% of patients with Kimura's disease, and 60-78% of kidney involvement is in the form of nephrotic syndrome. 4,5 Although various types of glomerulonephritis, such as membranous glomerulonephritis, mesangial proliferative glomerulonephritis, minimal-change disease, focal segmental glomerulosclerosis, and diffuse proliferative glomerulonephritis, have been reported to be associated with Kimura's disease, 6 only 2 cases of Immunoglobulin A (IgA) nephropathy have been reported in Kimura's disease to date; thus, the association between these 2 diseases remains unclear.…”

Section: Introductionmentioning

confidence: 99%