Treatment of keloids by high-dose-rate brachytherapy: A seven-year study

Guix, B.; Henrı́quez, I.; Andrés, Augusto; Finestres, F.; Tello, J.; Martı́nez, Antonio

doi:10.1016/s0360-3016(00)01563-7

Cited by 141 publications

(100 citation statements)

References 13 publications

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“…Superficial x-rays, electron-beam therapy and low-or highdose-rate brachytherapy have been used with good results in scar reduction protocols, primarily as adjuncts to surgical removal of keloids (120). The effects of radiation on keloids are thought to be mediated through inhibition of neovascular buds and proliferating fibroblasts, which result in decreased collagen production (93).…”

Section: Current Treatment Strategiesmentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,141

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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Section: Current Treatment Strategiesmentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,141

1,012

View full text Add to dashboard Cite

show abstract

“…While keloid radiotherapy alone, without surgery, is the exception, postoperative keloid radiotherapy is very effective, and according to many authors the therapy of choice. This combination brings recurrence rates down to 12-28% [2,12,13,14,17,19,21,30].…”

Section: Discussionmentioning

confidence: 99%

“…It remains unclear which kind of radiotherapy is best suited. Reliable keloid prophylaxis is possible for a series of radiotherapeutic methods and various fractionation dose schedules [12,20,27,34]. The following radiotherapies are currently available: X-ray therapy, contact therapy with 90 Sr and 90 Y, radium therapy, brachytherapy in after-loading technique with 192 Ir wires and irradiation with fast electrons from a linear accelerator.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies has shown that recurrence rates can be significantly reduced to 2-36% [2,5,8,12,14,17,20,22,24,30,36]. The actual mechanism is not yet understood, although Trott [34] has proposed that the mode of action of radiation in the treatment of connective tissue hypertrophy is based on proliferation inhibition and accelerated fibroblast differentiation.…”

Section: Introductionmentioning

confidence: 99%

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Radiotherapy in the Management of Keloids Clinical Experience with Electron Beam Irradiation and Comparison with X-Ray Therapy

Maarouf¹,

Schleicher²,

Schmachtenberg³

et al. 2002

Strahlenther Onkol

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“…However, since the safety and efficacy of radiation therapy have improved markedly in recent years, radiation is now used routinely as a highly effective postoperative adjuvant therapy. As a result, keloids can be treated with high dose rate-superficial brachytherapy (HDR-SB) 21,22 , as well as electron beam irradiation 23 25 . Depending on the shape of the surgical scar, an HDR-SB applicator can be used to ensure both the evenness and appropriate localization of the radiation to the wound surface.…”

Section: B Radiationmentioning

confidence: 99%

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy

et al. 2016

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Keloids and hypertrophic scars are fibroproliferative disorders of the skin that are caused by abnormal healing of injured or irritated skin. It is possible that they are both manifestations of the same fibroproliferative skin disorder and just differ in terms of the intensity and duration of inflammation. These features may in turn be influenced by genetic, systemic, and local risk factors. Genetic factors may include single nucleotide polymorphisms, while systemic factors may include hypertension, pregnancy, hormones, and cytokines. The most important local factor is tension on the scar. Over the past 10 years, our understanding of the pathogenesis of keloids and hypertrophic scars has improved markedly. As a result, these previously intractable scars are now regarded as being treatable. There are many therapeutic options, including surgery, radiation, corticosteroids, 5-fluorouracil, cryotherapy, laser therapy, antiallergy agents, anti-inflammatory agents, bleaching creams and make-up therapies. However, at present, we believe that the following combination of three therapies most reliably achieves a complete cure: surgery, followed by radiation and the use of steroid tape/plaster. (J Nippon Med Sch 2016; 83: 46 53)

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Treatment of keloids by high-dose-rate brachytherapy: A seven-year study

Cited by 141 publications

References 13 publications

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Radiotherapy in the Management of Keloids Clinical Experience with Electron Beam Irradiation and Comparison with X-Ray Therapy

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy

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