Treatment of keloids by combined surgical excision and immediate postoperative x-ray therapy

Surgery and Perioperative Intralesional Corticosteroid Injection for Treating Earlobe Keloids: A Korean Experience

“…Although the recurrence rate of interferon injection after excision is known to be low, interferon treatment is more expensive than TA intralesional injection and the results are similar to ours. Recurrence rates of as low as 2%, but up to 50%, have been reported following postoperative external-beam radiotherapy 21,22 . A randomized controlled trial of earlobe keloid excision followed by either intralesional steroid injection or radiotherapy has shown that radiotherapy has a lower recurrence rate than that of steroid injection, a statistically significant difference was not observed 23 .…”

Radiation following percutaneous balloon aortic valvuloplasty to prevent restenosis (RADAR pilot trial)

“…In noncardiovascular procedures (plastic and orthopedic surgery), these cell-mediated processes are effectively prevented using EBRT. Numerous EBRT protocols exist for keloid prophylaxis varying both in dose (800-1,800 cGy) and in number of fractions 1-6 [10][11][12]. Protocols following orthopedic procedures to prevent heterotopic ossification also vary in total dose (700-2,000 cGy) and number of fractions 1-10 [10,13,14].…”

“…In the low-dose group (patients 1-10), there were five deaths (2 cardiac) and 1 surgical AVR, yielding 6 MAE events (60%) at 1 year. In the high-dose group (patients [11][12][13][14][15][16][17][18][19][20], there were three deaths (1 cardiac) and no reintervention, resulting in a total MAE rate of 30%. For the entire group of 20 patients, the MAE rate was 45%.…”

Optimization of treatment and prevention of scars

“…Многие авторы докладывали об успешном более чем в 80% наблюдений иссечении келоидных рубцов с после-дующим облучением послеоперационной раны [81,92]. При этом частота развития рецидива снижалась до 10% [64,74].…”