Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study

Saray, Yasemin; Güleç, A. Tülin

doi:10.1111/j.1365-4632.2005.02633.x

Cited by 131 publications

(137 citation statements)

References 32 publications

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“…After administering three to five intralesional injections of bleomycin within a 1-month period, the authors observed complete regression in 69.4% of the keloids. Subsequent studies revealed similar results, with significant improvement in hypertrophic scar and keloid height and pliability as well as reduction in erythema, pruritus and pain (135,137,138). Occasionally, development of hyperpigmentation and dermal atrophy may occur with bleomycin treatment.…”

Section: Current Treatment Strategiessupporting

confidence: 54%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,148

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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Section: Current Treatment Strategiessupporting

confidence: 54%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,148

1,012

View full text Add to dashboard Cite

show abstract

“…The recommended dosage starts at 0.1 ml (1.5 IU/ml) and can go up to a maximum dose of 6 ml in order to prevent adverse effects which are usually cutaneous and less common pulmonary. 31,32 For patients with old scars that do not respond to intralesional steroid, the recommended treatment is between 2 and 6 sessions per month. Bleomycin usage is still uncommon in the clinical practice.…”

Section: Bleomycinmentioning

confidence: 99%

Novel Insights on Understanding of Keloid Scar: Article Review

Mari

Alsabri

Tabal

et al. 2015

Journal of the American College of Clinical Wound Specialists

123

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Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. In this review, PubMed, clinical key and Wright State Library web site have been used to investigate any update regarding Keloid disease. We used Keloid, scar formation, hypertrophic scar and collagen as key words. More than 40 articles have been reviewed. This paper reviews literature about keloid scar formation mechanism, the most recent therapeutic options including the ones under research.

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“…Mögliche Nebenwirkungen sind Hautirritationen, Schmerzen während der Injektion, Ulzerationen und Purpura. Auch über intraläsionales Bleomycin existieren durchaus positi− ve Studienergebnisse [24,25]. Durch ein ¹Einpricken" der Sub− stanz, d. h. externes Auftragen und anschließende Punktion mit einer Nadel, findet eine geringere Resorption statt.…”

Section: Intraläsionale Zytostatikaunclassified

Narbe und Keloid – und nun?

Heinlin¹,

Landthaler²,

Karrer³

2008

Akt Dermatol

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Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study

Abstract: Intralesional jet injection of bleomycin is an effective and safe method of treating keloids and hypertrophic scars that are unresponsive to intralesional steroid therapy.

Cited by 131 publications

References 32 publications

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Novel Insights on Understanding of Keloid Scar: Article Review

Narbe und Keloid – und nun?

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