Treatment of Intractable Narcolepsy with a Monoamine Oxidase Inhibitor

Wyatt, Richard Jed; Fram, David H.; Buchbinder, Rona; Snyder, Frederick

doi:10.1056/nejm197110282851802

Cited by 114 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter patients have normal REM sleep and rarely develop the narcoleptic syndrome (Passouant et al, 1968). Amphetamines suppress REM sleep (Rechtschaffen and Marron, 1964), and this may account for their action in narcolepsy, rather than any stimulant effect on the central nervous system; phenelzine which abolishes REM sleep also abolishes narcolepsy (Wyatt et al, 1971). Despite the action of l(-) amphetamine in reducing the frequency of narcoleptic attacks, the EEG evidence suggests that the drug has no effect on the EEG patterns of narcoleptic diurnal sleep.…”

Section: Discussionmentioning

confidence: 99%

Levo(-) amphetamine and dextro(+) amphetamine in the treatment of narcolepsy

Parkes¹,

Fenton²

1973

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

SUMMARY The narcoleptic syndrome is a life-long and sometimes familial disorder in which there is a disturbance of the rapid eye movement phase of sleep. Patients with periodic sleep in the daytime but no other symptoms seldom develop the narcoleptic syndrome and have a separate unrelated disorder. Twelve patients with the narcoleptic syndrome were treated separately with l(-) amphetamine and d( +) amphetamine. Both drugs abolished narcolepsy, d( +) amphetamine being slightly more potent than l(-) amphetamine. In equipotent doses, unwanted effects of nervousness and insomnia were equal in frequency. No tolerance to either preparation developed during a six month period. Cataplexy was not affected by amphetamine treatment, but was abolished in two patients when clomipramine was given together with either amphetamine.

show abstract

Section: Discussionmentioning

confidence: 99%

Levo(-) amphetamine and dextro(+) amphetamine in the treatment of narcolepsy

Parkes¹,

Fenton²

1973

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…All three of the men in one trial complained of difficulty getting erections during the initial weeks on the drug (Wyatt 1971). Two of the four women reported orgasmic difficulty.…”

Section: Phenelzine (Nardi!®)mentioning

confidence: 97%

“…This is an MAO-inhibitor antidepressant that has reported effects of impotence in men and difficulty in achieving orgasm in both women and men (Glass 1981;Barton 1979;Rapp 1979;Wyatt 1971). All three of the men in one trial complained of difficulty getting erections during the initial weeks on the drug (Wyatt 1971).…”

Section: Phenelzine (Nardi!®)mentioning

confidence: 99%

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Buffum

1982

Journal of Psychoactive Drugs

154

View full text Add to dashboard Cite

The literature on the sexual side effects of drugs and chemicals has been reviewed. There are many substances which alter the human sociosexual response cycle either negatively, positively or both. Many of the drugs used therapeutically have been reported to have adverse effects on sexuality, and this must be taken into account when these drugs are used clinically. Many substances which are used for recreational purposes (or sometimes abused) also have profound effects on sexual response. Many of these substances are used in such a way that they can correct underlying sexual problems. Treatment of a drug abuser may well prove unsuccessful without consideration of preexistent sociosexual problems and concerns. From the dawn of recorded history, many substances have been used for the purpose of sexual enhancement. Some of these have known success and their reputations have been passed down through the millenia. The chapter has not yet been closed on aphrodisiacs, even though none have survived the rigors of scientific scrutiny. As long as humans place value on optimal sexual functioning, there will be a demand for sex-enhancing drugs. In order for the scientific and medical community to successfully meet these challenges, more effective and relevant study designs will have to be utilized in order to separate fact from fancy. The study of pharmacosexology is in its infancy, and in order for it to grow and contribute to the world body of knowledge, more researchers and clinicians must be trained in both pharmacology and sexology.

show abstract

“…Although these drugs, specially phenelzine, have been used with success in small series (Wyatt et al 1971), they lack controlled clinical trials. Moreover these drugs have adverse effects including orthostatic hypotension, edema, weight gain, and impotence.…”

Section: Monoamine Oxidase (Mao) Type-a Inhibitorsmentioning

confidence: 99%

Narcolepsy: current treatment options and future approaches

Billiard¹

2008

NDT

View full text Add to dashboard Cite

Abstract:The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1) Two tendencies characterize the conventional treatment of narcolepsy. Modafi nil has replaced methylphenidate and amphetamine as the fi rst-line treatment of excessive daytime sleepiness (EDS) and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafi nil, but on no direct comparison of modafi nil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2) The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good effi cacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3) A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy.

show abstract

Treatment of Intractable Narcolepsy with a Monoamine Oxidase Inhibitor

Cited by 114 publications

References 11 publications

Levo(-) amphetamine and dextro(+) amphetamine in the treatment of narcolepsy

Levo(-) amphetamine and dextro(+) amphetamine in the treatment of narcolepsy

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Narcolepsy: current treatment options and future approaches

Contact Info

Product

Resources

About