2013
DOI: 10.1590/0103-6440201302169
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Abstract: Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients we… Show more

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Cited by 10 publications
(33 citation statements)
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References 26 publications
(33 reference statements)
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“…Surprisingly, only two RCT studies (three articles) have been reported in the literature and none of the biomaterials used could be affiliated with better outcomes. In Queiroz et al's study, the use of a nonresorbable barrier resulted in similar changes to those obtained in patients in which the bone substitute was mixed with P-15 without any membrane [33]. In Rakmanee et al's research, both clinical and radiographic results showed substantial comparability between GTR procedures and access flap therapies [27,34].…”
Section: Discussionmentioning
confidence: 77%
“…Surprisingly, only two RCT studies (three articles) have been reported in the literature and none of the biomaterials used could be affiliated with better outcomes. In Queiroz et al's study, the use of a nonresorbable barrier resulted in similar changes to those obtained in patients in which the bone substitute was mixed with P-15 without any membrane [33]. In Rakmanee et al's research, both clinical and radiographic results showed substantial comparability between GTR procedures and access flap therapies [27,34].…”
Section: Discussionmentioning
confidence: 77%
“…A summary of the studies' characteristics is presented in Table . Two RCT (three articles) were found to be moderate risk of bias . Of the other included studies, 12 were case reports; one was a retrospective study; and six were non‐randomized, comparative studies .…”
Section: Resultsmentioning
confidence: 99%
“…Most of the included studies reported the outcomes obtained after the treatment of young participants, apparently confirming that AgP seemed to be related to the age of development. However, it should be noted that some studies considered patients' age as an inclusion criteria, thus limiting a priori the number of older participants. This aspect is a direct consequence of the fact that age of onset was considered a diagnostic criterion.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies demonstrated the regenerative potential of GTR to promote periodontal regeneration (3,5). The clinical efficacy of this procedure for Class II furcation regeneration was established in a meta-analysis carried out by Kinaia et al (18).…”
Section: Discussionmentioning
confidence: 99%
“…Expanded polytetrafluoroethylene (ePTFE) membrane is a non-resorbable material extensively investigated for the treatment of periodontal defects, with significant gains in new attachment (5). The period for membrane removal varies from 4 to 6 weeks after placement (6); a previous study has shown the benefit of ePTFE membrane retrieval at this time (7), and longer periods did not provide additional benefits (8).…”
Section: Introductionmentioning
confidence: 99%