Treatment of intimal sarcoma of peripheral veins

López-Gómez, Javier; Flores-Vázquez, Erwin R.; Salazar-Álvarez, Ma. Alejandra; Adame, Rodrigo Y.; García-Ortega, Dorian Yarih; Cuéllar-Hübbe, Mario

doi:10.1016/j.ijscr.2017.01.018

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…[6] The incidence of intimal sarcoma of pulmonary artery has been reported to be nearly twice of the aorta, primarily involving the proximal end of the blood vessel. [1] So far, approximately 200 intimal sarcoma cases have been reported. In a review of studies in the last 10 years, apart from the report by Afzal et al, only 1 article published by Zhang et al in 2019 reported a 66-year-old case who developed high-grade undifferentiated intimal sarcoma that extended from IVC with involvement of nearly whole right atrium, venae iliaca communis and bilateral renal vasculature.…”

Section: Discussionmentioning

confidence: 99%

“…Intimal sarcoma is non-myogenic sarcoma originating from the tunica intima or related with large blood vessels. [1] It has been reported that intimal sarcoma accounts for only 1% of all sarcomas, which is commonly seen in aorta and pulmonary artery, but are rare in inferior vena cava (IVC). [2] It occurs mostly in older age groups, with an average age at diagnosis of 48 years for pulmonary intimal sarcoma patients and 62 years old for subjects with peripheral large veins or aortic intimal, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Tislelizumab combined with GT chemotherapy for intimal sarcoma of inferior vena cava: A case report

Liao,

Fang,

et al. 2024

Medicine

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Rationale: Intimal sarcoma of inferior vena cava (IVC) is a rare soft tissue sarcoma with no typical symptoms and specific imaging features in the early stage, and there is a lack of standardized treatment and methods. Patient concerns: A 54-year-old female patient presented to Fenghua District People’s Hospital with a post-active cough and hemoptysis and was subsequently referred to our hospital. Diagnoses: The patient was pathologically diagnosed as intimal sarcoma of IVC complicating multiple intrapulmonary metastases. Chest CT revealed left lung malignant tumor with multiple intrapulmonary metastases; while enhanced upper abdominal CT showed cancer embolus of IVC with extension to right atrium and bilateral renal veins. Besides, hematoxylin and eosin staining suggested intimal sarcoma of veins. Immunohistochemical staining showed positivity for PD-L1, Ki-67, CD31, Desmin and ERG. Interventions: The patient initially received GT chemotherapy (gemcitabine injection + docetaxel). Then, immunotherapy (tislelizumab) was added based on the results of genetic testing (TP53 gene mutation). Outcomes: The disease was stabilized after receiving the treatment. Lessons: Given the lack of characteristic clinical manifestations in patients with intimal sarcoma of IVC, imaging examination combined with immunohistochemical index were helpful for diagnosis of intimal sarcoma of IVC. Furthermore, the combination of tislelizumab and GT chemotherapy was feasible in such patients with positive PD-L1 expression and TP53 mutation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tislelizumab combined with GT chemotherapy for intimal sarcoma of inferior vena cava: A case report

Liao,

Fang,

et al. 2024

Medicine

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“…The primary sarcomas of the major blood vessels can be divided into three categories based on their site of origin: (a) the pulmonary artery (PA), (b) the aorta and its branches, and (c) the large veins (extremely rare group) . ISs, nonmyogenic sarcomas derived from the intima, are typically seen in the arterial system, particularly the PA, and are exceedingly rare in the IVC .…”

Section: Discussionmentioning

confidence: 99%

Intimal sarcoma of the inferior vena cava with extension to the right atrium, bilateral renal vasculature, and bilateral venae iliaca communis, accompanied by severe thrombocytopenia

et al. 2019

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A 66-year-old Asian female diagnosed with an occupied mass of the inferior vena cava (IVC) case with extension to the right atrium, bilateral renal vasculature, and venae iliaca communis, which caused severe thrombocytopenia and severe liver and kidney dysfunction. The postoperative pathological diagnosis was high-grade undifferentiated intimal sarcoma. There have been less than 10 cases of venous undifferentiated intimal sarcomas reported in the literature, three of which occurred in the IVC. Unfortunately, the patient died of multiple organ failure in the intensive care unit postoperatively. K E Y W O R D S cardiac sarcoma, inferior vena cava, intimal sarcoma, thrombocytopenia J Card Surg. 2019;34:506-510. wileyonlinelibrary.com/journal/jocs 506 | Abbreviations: HIT, heparin-induced thrombocytopenia; IVC, inferior vena cava; PA, pulmonary artery.

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Leiomyosarcoma of the basilic vein, a rare tumour at an exceptional location. A case report.

Navarro¹,

Martínez²,

Espinosa³

2019

Angiologia

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Treatment of intimal sarcoma of peripheral veins

Cited by 4 publications

References 29 publications

Tislelizumab combined with GT chemotherapy for intimal sarcoma of inferior vena cava: A case report

Tislelizumab combined with GT chemotherapy for intimal sarcoma of inferior vena cava: A case report

Intimal sarcoma of the inferior vena cava with extension to the right atrium, bilateral renal vasculature, and bilateral venae iliaca communis, accompanied by severe thrombocytopenia

Leiomyosarcoma of the basilic vein, a rare tumour at an exceptional location. A case report.

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