Treatment of Intervertebral Disc Degeneration

Xin, Jingguo; Wang, Yongjie; Zheng, Zhi; Wang, Shuo; Na, Shibo; Zhang, Shaokun

doi:10.1111/os.13254

Cited by 90 publications

(72 citation statements)

References 172 publications

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“…Therefore, IDD is difficult to repair by itself and is irreversible. In view of this feature, more and more teams have begun to use stem cells to intervene in the IDD process in order to slow down the IDD process or repair the degenerated intervertebral disc, including mesenchymal stem cells (MSC), intervertebral disc-derived stem cells (IVDSC), and pluripotent stem cells (PSC) [55]. 4.2.4.…”

Section: Cluster #2 Intervertebral Disc Degeneration Iddmentioning

confidence: 99%

Researches on Stem and Progenitor Cells in Intervertebral Discs: An Analysis of the Scientific Landscape

Cheng

Yang

Hai

et al. 2022

Stem Cells International

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Low back pain (LBP) is a common clinical symptom, and the prevalence is ranged from 60% to 70%. With the deepening of basic research, the development of intervertebral disc regeneration-oriented cell therapy, especially stem and progenitor cells therapy, showed good research prospects and was expected to become new methods of treatment for LBP. Our study is aimed at analyzing the scientific output of stem and progenitor cells in intervertebral discs and at driving future research into new publications. Researches focused on this file were searched from the Science Citation Index Expanded (SCI-E) of the Web of Science (WOS) core collection database and were screened according to inclusion criteria. We evaluated and visualized the results, including annual publications, citations, authors, organizations, countries, research directions, funds, and journals by bibliometric website, VOSviewer, and Citespace softwares on May 27, 2022. A total of 450 original articles and reviews were included, and the overall trend of the number of publications rapidly increased. In worldwide, China and the USA were the leading countries for research production. The retrieved 450 publications received 14322 citations, with an average of 31.83 citations and an H-index of 62. The most high-yield author, organization, country, research directions, funds, and journals were Chen QX from Zhejiang University, Zhejiang University, China, Cell Biology, National Natural Science Foundation of China, and Spine, respectively. Keywords cluster analysis showed the research hotspots in the future, including “human intervertebral disc”, “adipose-derived mesenchymal stem cell”, “intervertebral disc degeneration”, “degenerative disc model”, “nucleus pulposus regeneration”, “human cartilage”, “3d culture”, “shrinkage-free preparation”, and “polylactide disc”. Furthermore, with accumulating evidence demonstrating the role of stem and progenitor cells in intervertebral discs, “microenvironment”, “activation”, “intervertebral disc degeneration”, and “oxidative stress” are becoming the research frontiers and trends.

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Section: Cluster #2 Intervertebral Disc Degeneration Iddmentioning

confidence: 99%

Researches on Stem and Progenitor Cells in Intervertebral Discs: An Analysis of the Scientific Landscape

Cheng

Yang

Hai

et al. 2022

Stem Cells International

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“…Clinical treatment for IVDD mainly includes drug therapy, bed rest, traction, acupuncture, massage, and electromagnetic or electrothermal therapy (Xin et al, 2022). Although these conservative treatments may relieve symptoms and reduce pain, they do not reverse IVDD (Oichi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Although these conservative treatments may relieve symptoms and reduce pain, they do not reverse IVDD (Oichi et al, 2020). Patients who cannot tolerate pain usually undergo surgical removal of the IVD or IVD fusion therapy (Xin et al, 2022). Surgical treatment eliminates the radicular pain caused by IVDD, as it fundamentally eliminates the source of LBP.…”

Section: Introductionmentioning

confidence: 99%

Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration

Xia

Yang²,

Hou³

et al. 2022

Front. Bioeng. Biotechnol.

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Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to psychological and economic burdens to patients. Physical therapy only delays pain in patients but cannot eliminate the cause of IVDD. Surgery is required when the patient cannot tolerate pain or has severe neurological symptoms. Although surgical resection of IVD or decompression of the laminae eliminates the diseased segment, it damages adjacent normal IVD. There is also a risk of re-protrusion after IVD removal. Cell therapy has played a crucial role in the development of regenerative medicine. Cell transplantation promotes regeneration of degenerative tissue. However, owing to the lack of vascular structure in IVD, sufficient nutrients cannot be provided for transplanted mesenchymal stem cells (MSCs). In addition, dead cells release harmful substances that aggravate IVDD. Extracellular vesicles (EVs) have been extensively studied as an emerging therapeutic approach. EVs generated by paracrine MSCs retain the potential of MSCs and serve as carriers to deliver their contents to target cells to regulate target cell activity. Owing to their double-layered membrane structure, EVs have a low immunogenicity and no immune rejection. Therefore, EVs are considered an emerging therapeutic modality in IVDD. However, they are limited by mass production and low loading rates. In this review, the structure of IVD and advantages of EVs are introduced, and the application of MSC-EVs in IVDD is discussed. The current limitations of EVs and future applications are described.

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“…Intervertebral disc degeneration (IDD) is believed to be the major cause of low back pain, placing a heavy load on healthcare systems worldwide [ 1 ]. The mechanisms of IDD pathogenesis are considerably complex and many factors can contribute to IDD, including genetics, age, and poor lifestyle habits [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

Huang

Zhang

et al. 2022

Journal of Immunology Research

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Background. With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear. Methods. In our study, 11 IRGs were chosen using differential analysis between nondisc degeneration and degenerative patients from the GEO database. Then, we utilized a random forest (RF) model to screen six candidate IRGs to predict the risk of IDD. A nomogram was developed on the basis of six candidate IRGs, and DCA showed that patients could benefit from the nomogram. Based on the selected significant IRGs, a consensus clustering approach was used to differentiate disc degeneration patients into two immune patterns (immune cluster A and B). The PCA algorithm was constructed to compute immune scores for every sample, to quantify immune patterns. The immune scores of immune cluster B patients were higher than those of immune cluster A. Results. Through differential expression analysis between healthy and IDD samples, 11 significant IRGs (CTSS, S100Z, STAT3, KLRK1, FPR1, C5AR2, RLN1, IFGR2, IL2RB, IL17RA, and IL6R) were recognized through significant IRGs. The “Reverse Cumulative Distribution of Residual” and “Boxplots of Residual” indicate that the RF model has minimal residuals. The majority of samples in the model have relatively small residuals, demonstrating that the model is better. Besides, the nomogram model was constructed based on importance and the IRGs with importance scores greater than 2 (FPR1, RLN1, S100Z, IFNGR2, KLRK1, and CTSS). The nomogram model revealed that decision-making based on an established model might be beneficial for IDD patients, and the predictive power of the nomogram model was significant. In addition, we identified two different immune cluster patterns (immune cluster A and immune cluster B) based on the 11 IRGs. We found that immune cluster A had significantly higher levels of MDSC, neutrophil, plasmacytoid dendritic cell, and type 17 T helper cell expression than immune cluster B. And we calculated the score for each sample to quantify the gene patterns. The patients in immune cluster B or gene cluster B had higher immune scores than those in immune cluster A or gene cluster A. Conclusion. In conclusion, IRGs play an extremely significant role in the occurrence of IDD. Our study of immune patterns may guide the strategies of prevention and treatment for IDD in the future.

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Treatment of Intervertebral Disc Degeneration

Cited by 90 publications

References 172 publications

Researches on Stem and Progenitor Cells in Intervertebral Discs: An Analysis of the Scientific Landscape

Researches on Stem and Progenitor Cells in Intervertebral Discs: An Analysis of the Scientific Landscape

Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration

Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

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