Treatment of infertile women with a deficient postcoital test with two antiestrogens: clomiphene and tamoxifen

Strategies to reduce multiple pregnancies due to ovulation stimulation

“…Endometrial thickness (70,71) and cervical mucus (72,73) may be affected favorably or unfavorably by CC, depending on whether the antiestrogen effect or the effects of increased estrogen concentrations are predominant. Thin endometrium and hostile mucus adversely affect pregnancy rates and can be treated by added estrogen in the same cycle (74) and by lowering the dose of CC or switching to TMX (71)(72)(73) in subsequent cycles.…”

“…Thin endometrium and hostile mucus adversely affect pregnancy rates and can be treated by added estrogen in the same cycle (74) and by lowering the dose of CC or switching to TMX (71)(72)(73) in subsequent cycles. Tamoxifen and the nonsteroidal aromatase inhibitor letrozole (LET) are both effective alternatives to CC for OI when oral medications and a low incidence of multiple pregnancy are desired.…”

The Effect of Clomiphene Citrate and Tamoxifen on the Cervical Mucus

“…However, other studies did not confirm the anti-estrogenic effect of CC and TMX on the cervical mucus secretion (11,12).…”

Clomiphene Citrate for Women with Unexplained Infertility

“…An increase from 11.0 motile sperm/HPF in the control cycle to 12.2 in the TMX cycle was not significant. Other studies showed no difference between cervical mucous alterations with either CC or TMX [47,51,52] or a decrease in mucus score for TMX compared to placebo [53].…”