Treatment of Infections Due to Multiresistant Neisseria gonorrhoeae with Sulbactam/Ampicillin

Rational antibiotic therapy and the position of ampicillin/sulbactam

“…AMS was typically administered as a single i.m. dose (1.5 g) or as a single oral dose of sultamicillin (1.5-2.25 g), both in combination with oral probenecid, and clinical success rates ranged from 95% to 100% for the parenteral formulation and 89-97% for sultamicillin [73][74][75][76][77][78]. The efficacy of AMS was comparable with that of ceftriaxone [73,74].…”

Experience with Ampicillin/Sulbactam in Severe Infections

“…In this context, an open, prospective study carried out in Korea assessed ampicillin/ sulbactam plus probenecid as treatment for N. gonorrhoeae urethritis in 45 adult male patients infected with beta-lactamaseproducing strains. 34 In vitro studies revealed a minimum inhibitory concentration (MIC) in 90% of isolates (MIC 90 ) of 4 µg/ml for ampicillin/sulbactam, compared with > 32 µg/ml for ampicillin alone. All patients received probenecid 1 g orally and either one or two vials of ampicillin/sulbactam administered intramuscularly (each vial contained ampicillin/sulbactam 1/0.5 g).…”

Beta-lactamase inhibitors from laboratory to clinic.

“…Therapeutic applications for the ampicillin-sulbactam combination include gynecological infections caused by anaerobes only or by mixed populations of aerobes and anaerobes (69), polymicrobial intraabdominal infections (136), soft-tissue, bone, and joint infections (97), and penicillinase-producing N. gonorrhoeae (84). Sulbactam alone was not judged sufficiently suitable for the treatment of uncomplicated gonorrhea (38).…”